A UNIFYING CONCEPT OF THE ETIOLOGY OF BREAST-CANCER
A UNIFYING CONCEPT OF THE ETIOLOGY OF BREAST-CANCER
复制标题
DOI：
10.1002/ijc.2910410505
复制
发表时间：
1988-05-15
影响因子：
6.4
通讯作者：
TRICHOPOULOS, D
中科院分区：
文献类型：
--
作者：
DEWAARD, F;TRICHOPOULOS, D
乳腺癌的许多风险因素在一个与癌前病变形成相关的发病框架中共同考虑。青春期和青春期的高能量饮食会增加乳腺癌前病变的发生。这一过程被足月妊娠所抵消，并且它们来得越早，这种病变的数量就越少。在以后的生活中，富含能量的饮食有助于肥胖的发生，而肥胖在绝经后会促进现有亚临床和临床乳腺癌的生长。在生命的两个阶段，营养因素通过内分泌机制发挥作用，其中雌激素起主要作用。
A number of risk factors for breast cancer are considered jointly in one pathogenetic framework which relates to the formation of pre‐cancerous lesions. Energy‐rich diet during puberty and adolescence enhances the occurrence of pre‐cancerous lesions in the breast. This process is counteracted by full‐term pregnancies, and the earlier they come the fewer the number of such lesions. Energy‐rich diet later in life contributes to the occurrence of obesity which, after menopause, enhances the growth of existing subclinical and clinical breast cancer. In both periods of life the nutritional factor exerts its effect through endocrine mechanisms in which oestrogens play a major part.