Individual propensity for arterial thrombosis.
Individual propensity for arterial thrombosis.
复制标题
动脉血栓形成的个体倾向。
DOI：
10.1161/01.atv.19.4.883
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Owen,WG
中科院分区：
文献类型：
--
作者：
Wysokinski,WE;McBane2nd,RD;Owen,WG
独立于血管病理学的动脉血栓形成倾向以前没有被实验或流行病学定义。为了解决个体动脉血栓形成倾向的存在，我们利用了先前开发的程序，该程序需要成对的猪颈动脉的创伤性（挤压）损伤以产生富含血小板的血栓。通过连续止血钳挤压损伤猪双侧颈动脉。血栓生成监测autologous 111 In标记的血小板和多普勒血流局部积累。在年龄和体型相似的动物队列中，血栓质量的最低至最高应答者跨越7倍范围，显示与剪切力、血小板或白细胞计数或纤维蛋白原或血管性血友病因子的血浆浓度无关。然而，颈动脉对之间的血栓沉积存在强的个体内相关性（r2=0.80;P<0.001）。对标准化刺激的血栓形成反应的广泛变化，不被剪切应力或典型的血液学变量所解释，似乎是个体的内在倾向。血栓生成的实验系统足以定量评估决定这种倾向的变量。
—Arterial thrombophilia independent of vascular pathology has not been previously defined either experimentally or epidemiologically. To address the existence of an individual propensity to arterial thrombosis, we exploited a previously developed procedure entailing traumatic (crush) injury of paired porcine carotid arteries for generating platelet-rich thrombi. Porcine carotid arteries were injured bilaterally by serial hemostat crushes. Thrombus generation was monitored by local accumulation of autologous111In-labeled platelets and Doppler blood flow. Within this cohort of animals of similar age and size, the lowest to the highest responders in thrombus mass spanned a 7-fold range, showing no correlation with shear, platelet or leukocyte count, or plasma concentrations of fibrinogen or von Willebrand factor. However, there was strong intra-individual correlation (r2=0.80;P<0.001) of thrombus deposition between carotid artery pairs. The wide variation in thrombotic response to a standardized stimulus, not accounted for by shear stress or typical hematological variables, appears to be an intrinsic propensity of the individual. The experimental system for thrombus generation is sufficiently quantitative for assessment of variables determining this propensity.