AIR BUBBLE ENDOTHELIAL DAMAGE DURING PHACOEMULSIFICATION IN HUMAN EYE BANK EYES - THE PROTECTIVE EFFECTS OF HEALON AND VISCOAT
AIR BUBBLE ENDOTHELIAL DAMAGE DURING PHACOEMULSIFICATION IN HUMAN EYE BANK EYES - THE PROTECTIVE EFFECTS OF HEALON AND VISCOAT
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DOI：
10.1016/s0886-3350(13)80777-8
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发表时间：
1990-09-01
影响因子：
2.8
通讯作者：
OLSON, RJ
中科院分区：
文献类型：
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作者：
CRAIG, MT;OLSON, RJ;OLSON, RJ
将 Healon（透明质酸钠）或 Viscoat（硫酸软骨素钠-透明质酸钠）插入人眼库眼睛的前房后，在超声乳化手术期间将受控量的小气泡引入前房。活体染色后，对中央角膜内皮细胞的损伤进行量化。在未使用粘弹性材料的眼睛（阳性对照）中，内皮损伤平均为 4.5%，而在插入粘弹性材料但未引入气泡的眼睛（阴性对照）中，内皮损伤仅为 0.4% (p < .001)。使用 Plus Healon 的测试样本中的内皮损伤平均为 4.9%。使用空气加 Viscoat 的测试样本的平均损坏率为 0.3% (P < .02)。正如扫描电子显微镜所证明的那样，阳性对照和 Healon 测试样本中的许多区域都被严重损坏，无法通过我们使用的方法进行准确定量。因此，Viscoat 可以防止或减轻超声乳化手术过程中小气泡对角膜内皮的损伤。
Following insertion of either Healon (sodium hyaluronate) or Viscoat (sodium chondroitin sulfate-sodium hyaluronate) into the anterior chamber of human eye bank eyes, a controlled amount of small air bubbles was introduced into the anterior chamber during phacoemulsification. After vital staining, damage to endothelial cells in the central cornea was quantified. Endothelial damage averaged 4.5% in eyes in which no viscoelastic was used (positive control), whereas damage was only 0.4% (p < .001) in eyes in which a viscoelastic was inserted but no air bubbles were introduced (negative control). Endothelial damage in test specimens using plus Healon averaged 4.9%. Damage in test specimens using air plus Viscoat averaged 0.3% (P < .02). As demonstrated by scanning electron microscopy, many areas in the positive controls and in the Healon test specimens were damaged too extensively to quantitate accurately by the method we used. Thus, Viscoat may prevent or lessen damage to the corneal endothelium by small air bubbles during phacoemulsification.