Semaphorin-plexin signaling guides patterning of the developing vasculature
Semaphorin-plexin signaling guides patterning of the developing vasculature
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DOI：
10.1016/j.devcel.2004.06.008
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发表时间：
2004-07-01
影响因子：
11.8
通讯作者：
Weinstein, BM
中科院分区：
文献类型：
--
作者：
Torres-Vázquez, J;Gitler, AD;Weinstein, BM
脊椎动物循环系统的主要血管显示进化上保守和可重复的解剖结构，但指导这种刻板模式的线索仍然不清楚。在神经系统中，轴突通路由脑信号蛋白家族的配体提供的排斥性线索形成，所述排斥性线索通过丛蛋白受体由迁移的神经元生长锥感测。我们表明，适当的血管寻路需要内皮受体丛蛋白D1和信号蛋白信号，我们确定在斑马鱼血管图案突变体的丛蛋白D1的突变出界。这些结果揭示了在血管生成过程中，中枢神经系统轴突迁移和血管内皮之间的排斥性模式化机制的基本保守性。
Major vessels of the vertebrate circulatory system display evolutionarily conserved and reproducible anatomy, but the cues guiding this stereotypic patterning remain obscure. In the nervous system, axonal pathways are shaped by repulsive cues provided by ligands of the semaphorin family that are sensed by migrating neuronal growth cones through plexin receptors. We show that proper blood vessel pathfinding requires the endothelial receptor PlexinD1 and semaphorin signals, and we identify mutations in plexinD1 in the zebrafish vascular patterning mutant out of bounds. These results reveal the fundamental conservation of repulsive patterning mechanisms between axonal migration in the central nervous system and vascular endothelium during angiogenesis.