Association of genetic variations with NAFLD in lean individuals
Association of genetic variations with NAFLD in lean individuals
复制标题
DOI：
10.1111/liv.15078
复制
发表时间：
2021-10-12
影响因子：
6.7
通讯作者：
Wong，Vincent W-S
中科院分区：
文献类型：
--
作者：
Lin，Huapeng;Wong，Grace L-H;Wong，Vincent W-S
背景与目的肥胖如何影响遗传变异对亚洲人群非酒精性脂肪肝 (NAFLD) 的影响仍不清楚。我们的目的是研究瘦、超重和肥胖个体中遗传风险变异与 NAFLD 易感性/严重程度之间的关联。方法对 904 名社区受试者进行了质子磁共振波谱和瞬时弹性成像检查。根据亚洲人的体重指数临界值定义瘦（<23 kg/m2）、超重（23‐24.9 kg/m2）和肥胖（≥25 kg/m2）。 NAFLD定义为肝内甘油三酯≥5%。通过rhAMPTMSNP检测分析PNPLA3、TM6SF2、MBOAT7等9个基因多态性。结果瘦、超重和肥胖分别为529例（58.5%）、162例（17.9%）和213例（23.6%）。三组中 NAFLD 的患病率分别为 12.4%、41.4% 和 59.1%（P<0.001）。在 NAFLD 患者中，瘦受试者 (30.3%) 比超重 (17.9%) 和肥胖受试者 (17.4%) 更有可能携带 PNPLA3rs738409 GG 基因型 (P=.003)。与CC基因型相比，与超重受试者（OR 3.43，95% CI [1.06，11.14]）和肥胖受试者（OR 2.51，95% CI [0.93，6.78]）相比，GG基因型与瘦受试者中NAFLD风险的最大增加相关（比值比[OR] 6.04）。此外，TM6SF2rs58542926 TT 基因型仅在瘦受试者中与血清甘油三酯降低相关。其他基因多态性没有观察到基因-BMI 效应。 结论 PNPLA3rs738409 基因多态性对亚洲瘦人的肝脏脂肪的影响比超重或肥胖的人更大。
Background & AimsHow adiposity influences the effect of genetic variants on non‐alcoholic fatty liver disease (NAFLD) in the Asian population remains unclear. We aimed to study the association between genetic risk variants and susceptibility/severity of NAFLD in the lean, overweight and obese individuals.MethodsNine hundred and four community subjects underwent proton‐magnetic resonance spectroscopy and transient elastography examination. Lean (<23 kg/m2), overweight (23‐24.9 kg/m2) and obesity (≥25 kg/m2) were defined according to the body mass index cut‐offs for Asians. NAFLD was defined as intrahepatic triglycerides ≥5%.PNPLA3,TM6SF2,MBOAT7and 9 other gene polymorphisms were analysed by rhAMPTMSNP assays.ResultsFive hundred and twenty‐nine (58.5%), 162 (17.9%) and 213 (23.6%) subjects were lean, overweight and obese, respectively. The prevalence of NAFLD was 12.4%, 41.4% and 59.1% in the three groups (P< .001). Amongst those with NAFLD, lean subjects (30.3%) were more likely to carry thePNPLA3rs738409 GG genotype than overweight (17.9%) and obese subjects (17.4%) (P= .003). Compared with the CC genotype, the GG genotype was associated with the greatest increase in the risk of NAFLD in lean subjects (odds ratio [OR] 6.04), compared with overweight (OR 3.43, 95% CI [1.06, 11.14]) and obese subjects (OR 2.51, 95% CI [0.93, 6.78]). Additionally, theTM6SF2rs58542926 TT genotype was associated with reduced serum triglycerides only in lean subjects. A gene‐BMI effect was not observed for the other gene polymorphisms.ConclusionsThePNPLA3rs738409 gene polymorphism has a greater effect on liver fat in Asian lean individuals than in overweight or obese ones.