BEHAVIORAL MEASUREMENT AND DRUG RESPONSE CHARACTERISTICS OF UNIPOLAR AND BIPOLAR DEPRESSION
BEHAVIORAL MEASUREMENT AND DRUG RESPONSE CHARACTERISTICS OF UNIPOLAR AND BIPOLAR DEPRESSION
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DOI：
10.1017/s0033291700043257
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发表时间：
1982-01-01
影响因子：
6.9
通讯作者：
SWANN, A
中科院分区：
文献类型：
--
作者：
KATZ, MM;ROBINS, E;SWANN, A
这项研究是 NIMH-CRB 抑郁症心理生物学合作研究的一部分。该研究计划的主要目标是检验有关抑郁症中神经生物学机制和行为相互作用的假设。报告的第一部分描述了衡量研究计划中行为状态和结果的基本原理和总体方法。第二部分报告了应用行为方法来比较单相和双相抑郁症的临床现象的结果。两组在发作期间表现出的行为模式是不同的。此外，这两种类型对三环类药物治疗的反应不同，这强化了这样的论点：它们是性质不同的抑郁症形式。
This research is part of the NIMH-CRB Collaborative Study on the psychobiology of depression. The main objective of the research programme is to test hypotheses concerning the interaction of neurobiological mechanisms and behaviour in the depressive disorders. Part I of the report describes the rationale and the overall approach to measuring behavioural state and outcome in the research programme. Part II reports on the results of applying the behavioural methods to a comparison of the clinical phenomenology of unipolar and bipolar depression. The behavioural patterns expressed during the episode by the two groups are different. Further, the two types are shown to react differently to treatment with tricyclic drugs, reinforcing the thesis that they are qualitatively distinct forms of the depressive disorders.