G-protein-coupled receptor kinases in inflammation and disease.
G-protein-coupled receptor kinases in inflammation and disease.
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DOI：
10.1038/gene.2015.26
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发表时间：
2015-09
影响因子：
5
通讯作者：
Parameswaran N
中科院分区：
文献类型：
--
作者：
Packiriswamy N;Parameswaran N
g蛋白偶联受体激酶（GRKs）是丝氨酸/苏氨酸蛋白激酶，最初因其在g蛋白偶联受体（GPCR）磷酸化中的作用而被发现。最近的研究表明，该激酶家族具有更广泛的功能，包括磷酸化参与由gpcr和非gpcr刺激的细胞信号通路的细胞质底物。此外，GRKs通过磷酸化无关的功能调节信号。由于这些不同的生化功能，GRKs已被证明可以影响关键的生理和病理生理过程，因此被认为是心力衰竭等疾病的药物靶点。grk在炎症和炎症性疾病中的作用是一个不断发展的研究领域，包括我们实验室近年来的一些研究已经证明了grk在免疫系统中的关键作用。在这篇综述中，我们讨论了GRKs在免疫系统中的经典和新出现的功能及其在炎症和疾病过程中的作用。
G-protein coupled receptor kinases (GRKs) are serine/threonine protein kinases originally discovered for their role in G-protein coupled receptor (GPCR) phosphorylation. Recent studies have demonstrated a much broader function for this kinase family including phosphorylation of cytosolic substrates involved in cell signaling pathways stimulated by GPCRs as well as non-GPCRs. In addition, GRKs modulate signaling via phosphorylation-independent functions. Because of these various biochemical functions, GRKs have been shown to affect critical physiological and pathophysiological processes and thus are considered as drug targets in diseases such as heart failure. Role of GRKs in inflammation and inflammatory diseases is an evolving area of research and several studies including work from our lab in the recent years have demonstrated critical role of GRKs in the immune system. In this review we discuss the classical and the newly emerging functions of GRKs in the immune system and their role in inflammation and disease processes.