Substance abuse and neurotransmission.
Substance abuse and neurotransmission.
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DOI：
10.1016/bs.apha.2021.10.007
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Zhu, Jun
中科院分区：
文献类型：
--
作者：
Davis, Sarah;Zhu, Jun
在过去十年中，患有药物滥用障碍的人数持续上升;特别是在COVID-19大流行期间，与药物相关的过量死亡人数急剧增加。在成像和神经心理学性能测试的支持下，临床观察的趋同线表明，药物滥用引起的大脑神经传递失调对于滥用药物成瘾特性的发展和表达至关重要。最近的科学进步使人们能够更好地了解介导药物滥用和成瘾的神经生物学过程。本章介绍了过去的经典概念和我们对可卡因、安非他明、阿片类药物、酒精和尼古丁如何改变多种神经递质系统的知识的最新进展，这些神经递质系统有助于与每种药物相关的行为。此外，我们还讨论了HIV-1或COVID-19和药物滥用对神经传递和神经生物学通路的相互作用。最后，我们介绍了药物治疗药物滥用障碍的发展的治疗策略。
The number of people who suffer from a substance abuse disorder has continued to rise over the last decade; particularly, the number of drug-related overdose deaths has sharply increased during the COVID-19 pandemic. Converging lines of clinical observations, supported by imaging and neuropsychological performance testing, have demonstrated that substance abuse-induced dysregulation of neurotransmissions in the brain is critical for development and expression of the addictive properties of abused substances. Recent scientific advances have allowed for better understanding of the neurobiological processes that mediates drugs of abuse and addiction. This chapter presents the past classic concepts and the recent advances in our knowledge about how cocaine, amphetamines, opioids, alcohol, and nicotine alter multiple neurotransmitter systems, which contribute to the behaviors associated with each drug. Additionally, we discuss the interactive effects of HIV-1 or COVID-19 and substance abuse on neurotransmission and neurobiological pathways. Finally, we introduce therapeutic strategies for development of pharmacotherapies for substance abuse disorders.