SCALEMIC 12-HYDROXYAMBLIOFURAN AND 12-ACETOXYAMBLIOFURAN, 5 TETRACYCLIC FURANODITERPENES AND A FURANOSESTERTERPENE FROM SPONGIA SP
SCALEMIC 12-HYDROXYAMBLIOFURAN AND 12-ACETOXYAMBLIOFURAN, 5 TETRACYCLIC FURANODITERPENES AND A FURANOSESTERTERPENE FROM SPONGIA SP
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DOI：
10.1016/s0040-4020(01)89605-8
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发表时间：
1994-08-15
期刊：
影响因子：
2.1
通讯作者：
MOLINSKI, TF
中科院分区：
文献类型：
--
作者：
SEARLE, PA;MOLINSKI, TF
从西澳海绵Spongia sp.中分离得到8个新化合物，包括12-羟基二氢呋喃（5）及其乙酸酯6、5个新的四环二萜7 - 11和环氧呋喃倍半萜羧酸12。化合物5和6，每一个分离为3：1的对映异构体的混合物，通过修改的Mosher酯方法和手性镧系元素NMR位移研究确定，是罕见的scalemic海洋天然产物的例子。
Eight new compounds were isolated from a Western Australian sponge Spongia sp., including 12-hydroxyambliofuran (5), its acetate ester 6, five new tetracyclic diterpenes 7 - 11 and the epoxyfuranosesterterpene carboxylic acid 12. Compounds 5 and 6, each isolated as a 3:1 mixture of enantiomers as determined by a modified Mosher's ester method and chiral lanthanide NMR shift studies, are rare examples of scalemic marine natural products.