The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis
The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis
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DOI：
10.7150/ijms.4733
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发表时间：
2012-01-01
影响因子：
3.6
通讯作者：
Kutanis, Riza
中科院分区：
文献类型：
--
作者：
Kaya, Bulent;Sana, Baris;Kutanis, Riza
背景：急腹症的早期诊断非常重要。迄今为止，几种炎症标志物已被用于诊断急腹症，包括急性阑尾炎。本研究的目的是评估D-二聚体、降钙素原（PCT）和C-反应蛋白（CRP）检测在急性阑尾炎中的诊断价值。方法：本研究于2010年3月1日至2011年7月1日进行。对78例诊断为急性阑尾炎的患者行手术治疗，并测定D-二聚体、PCT和CRP水平。根据手术结果和病理组织学结果将患者分为阑尾炎（1组）、坏疽性阑尾炎（2组）、穿孔性阑尾炎（3组）和阴性阑尾切除术（4组）。在78例患者中，54例（69.2%）为男性，24例（30.8%）为女性，平均年龄为25.4 ± 11.1岁（范围：18 - 69岁）。66例（84.6%）患者白细胞计数（白色血细胞计数）升高。PCT值高于正常上限20例（25.6%），其次是D-二聚体22例（28.2%）和CRP 54例（69.2%）。白细胞计数和C反应蛋白对急性阑尾炎的诊断价值高于其他指标，而白细胞计数的特异性很低。穿孔性阑尾炎的CRP值高于穿孔性阑尾炎（p
BACKGROUND: The early diagnosis of acute abdomen is of great importance. To date, several inflammatory markers have been used for the diagnosis of acute abdominal conditions, including acute appendicitis. The aim of this study was to evaluate the diagnostic utility of D-dimer, Procalcitonin (PCT) and C-reactive protein (CRP) measurements in the acute appendicitis.METHODS: This prospective study was conducted between March 1st, 2010 and July 1st, 2011. In this period, seventy-eight patients were operated with the diagnosis of acute appendicitis, and D-dimer, PCT and CRP levels of the patients were measured. The patients were grouped as phlegmonous appendicitis (Group 1), gangrenous appendicitis (Group 2), perforated appendicitis (Group 3) and negative appendectomy (Group 4) according to the surgical findings and histopathological results.RESULTS: Of 78 patients, 54 (69.2%) were male and 24 (30.8%) were female, and the mean age was 25.4 +/- 11.1 years (range, 18 to 69 years). 66 (84.6%) patients had increased leukocyte count (white blood cell count). The PCT values were higher than the upper normal limit in 20 (25.6%) patients, followed by D-dimer in 22 (28.2%) patients and CRP in 54 (69.2%) patients. The diagnostic value of leukocyte count and CRP in acute appendicitis was higher than that of the other markers, whereas leukocyte count showed very low specificity. CRP values were higher in perforated appendicitis when compared with the phlegmonous appendicitis (p