Relationships Between Early Maternal Warmth and Social Connection: A Randomized Clinical Trial With Naltrexone.
Relationships Between Early Maternal Warmth and Social Connection: A Randomized Clinical Trial With Naltrexone.
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DOI：
10.1097/psy.0000000000000986
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发表时间：
2021-10-01
影响因子：
3.3
通讯作者：
Inagaki TK
中科院分区：
文献类型：
--
作者：
Ross LP;Andreescu C;Inagaki TK
接受母亲温暖的早期经历预示着在以后的生活中与他人联系的机会的反应。然而，对这种关系出现的神经化学机制的理解仍然不完整。内源性阿片类物质，参与动物和人类的社会联系，可能有助于这种联系。因此，目前的研究检查了（1）早期母亲温暖和大脑之间的关系以及对新社会目标（即，可能促进社会联系的结果）和（2）阿片拮抗剂纳洛酮对这种关系的影响。82名成年参与者完成了早期母亲温暖的回顾性报告。在第二次访问时，参与者被随机分配到50 mg口服纳洛酮（n=42）或安慰剂（n=40），然后进行MRI扫描，其中评估了对新的社会目标（陌生人）图像的功能性大脑活动。大约24小时后，参与者报告了他们离开扫描仪后的社交感觉。在安慰剂条件下，母亲早期更温暖与背侧前扣带皮层、前额叶、腹侧纹状体和杏仁核对新的社会目标图像的反应较少相关（r =-0.360，p = 0.031），与实验室外更大的社会联系感觉相关（r= 0.524，p<0.001）。然而，在纳洛酮条件下不存在相同的关系。结果突出了早期母亲温暖和对整个社会世界的反应之间的关系，并表明阿片类药物可能有助于社会联系，通过支持温暖的早期生活经历对以后生活中的社会联系的缓冲作用。临床试验NCT 02818036
Early experiences of having received maternal warmth predict responses to opportunities to connect with others later in life. However, understanding of neurochemical mechanisms by which such relationships emerge remain incomplete. Endogenous opioids, involved in social connection in both animals and humans, may contribute to this link. Therefore, the current study examined (1) relationships between early maternal warmth and brain and self-report responses to novel social targets (i.e., outcomes that may promote social connection) and (2) the effect of the opioid antagonist, naltrexone, on such relationships. Eighty-two adult participants completed a retrospective report of early maternal warmth. On a second visit, participants were randomized to 50mg of oral naltrexone (n=42) or placebo (n=40) followed by an MRI scan where functional brain activity in response to images of novel social targets (strangers) was assessed. Approximately 24 hours later, participants reported on their feelings of social connection since leaving the scanner. In the placebo condition, greater early maternal warmth was associated with less dorsal anterior cingulate cortex, anterior insula, ventral striatum, and amygdala activity in response to images of novel social targets (r’s−.360, p’s.031), and greater feelings of social connection (r=.524, p<.001) outside of the lab. The same relationships, however, were not present in the naltrexone condition. Results highlight relationships between early maternal warmth and responses to the social world at large and suggest that opioids might contribute to social connection by supporting the buffering effects of warm early life experiences on social connection later in life. Clinical Trials NCT02818036