Medicinal use of Cochlospermum tinctorium in Mali Anti-ulcer-, radical scavenging- and immunomodulating activities of polymers in the aqueous extract of the roots
Medicinal use of Cochlospermum tinctorium in Mali Anti-ulcer-, radical scavenging- and immunomodulating activities of polymers in the aqueous extract of the roots
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DOI：
10.1016/j.jep.2004.09.018
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发表时间：
2005-01-01
影响因子：
5.4
通讯作者：
Paulsen, BS
中科院分区：
文献类型：
--
作者：
Nergard, CS;Diallo, D;Paulsen, BS
金鸡儿(Cochlosperum tincturum A.Rich)(Cochlospermaceae)是西非国家马里的一种广泛使用的药用植物。进行了民族药物学调查，采访了106名传统从业者。根是据报道最常用于药用的植物部分。主治黄疸41例，胃肠疾患28例，疟疾12例，血吸虫病10例，尿毒症6例。高分子量水提物(25，50和100 mg/kg，体重)显著抑制盐酸/乙醇诱导的小鼠胃损伤。该提取物在体外具有清除DPPH自由基和免疫调节活性。其主要成分为多糖(59.3%)和多酚(9.3%)。纯化得到的多糖为高度复杂的果胶阿拉伯半乳糖II型。作为多酚化合物的一部分，鉴定出没食子单宁和阿魏酸。这项研究表明，多糖是体外观察到的生物活性的部分原因。多糖和多酚可能与所观察到的抗溃疡活性有关。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
Cochlospermum tinctorium A. Rich. (Cochlospermaceae) is a widely used medicinal plant in the West African country, Mali. An ethnopharmacological survey was conducted and 106 traditional practitioners interviewed. The roots were the part of the plant reported to be the most frequently used for medicinal purposes. The main indications were to treat jaundice (41), gastro intestinal diseases or ailments (28), malaria (12), schistosomiasis (10) and dysurea (6). A high-molecular weight water extract (25, 50 and 100 mg/kg, body weight) significantly inhibited HCl/ethanol-induced gastric lesions in mice. The extract showed DPPH-radical scavenging- and immunomodulating activities in vitro. The main components of the extract were identified as polysaccharides (59.3%) and polyphenols (9.3%). The polysaccharides were purified and characterised as highly complex pectic arabinogalactans type II. As parts of the polyphenol compounds gallotannins and ferulic acids were identified. This study shows that the polysaccharides are partly responsible for the bioactivities observed in vitro. Both polysaccharides and polyphenols may be responsible for the anti-ulcer activities observed. (C) 2004 Elsevier Ireland Ltd. All rights reserved.