Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.
Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.
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DOI：
10.1016/j.celrep.2023.113153
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发表时间：
2023-10-31
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
食物过敏的日益流行与共生微生物多样性的减少有关。在本文中，我们描述了具有过敏保护作用的梭状芽胞杆菌的两个特征，这些特征有助于其发挥有益作用。一些梭菌类群带有鞭毛（TLR5 的配体）并产生吲哚（芳烃受体 [AhR] 的配体）。来自梭状芽孢杆菌菌群的裂解物和鞭毛诱导回肠外植体分泌白细胞介素 22 (IL-22)。在 CD11c+ 抗原呈递细胞中 TLR5 或 MyD88 信号传导全面或有条件缺陷的小鼠的外植体中，IL-22 的产生被消除。 RORγt+ 细胞中的 AhR 信号传导对于诱导 IL-22 是必需的。 RORγt+细胞中缺乏AhR的小鼠表现出肠道通透性增加，并且更容易对食物产生过敏反应。我们的研究结果表明 TLR5 和 AhR 信号传导参与了共生梭菌防止食物过敏反应的分子机制。肠道细菌数量的减少与食物过敏患病率的增加有关。肯特等人。表明来自共生梭菌的 AhR 配体和鞭毛调节肠道屏障通透性，以限制过敏原进入体循环并防止对食物的过敏反应。
The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of allergy-protective Clostridia that contribute to their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole (a ligand for the aryl hydrocarbon receptor [AhR]). Lysates and flagella from a Clostridia consortium induced interleukin-22 (IL-22) secretion from ileal explants. IL-22 production is abrogated in explants from mice in which TLR5 or MyD88 signaling is deficient either globally or conditionally in CD11c+ antigen-presenting cells. AhR signaling in RORγt+ cells is necessary for the induction of IL-22. Mice deficient in AhR in RORγt+ cells exhibit increased intestinal permeability and are more susceptible to an anaphylactic response to food. Our findings implicate TLR5 and AhR signaling in a molecular mechanism by which commensal Clostridia protect against allergic responses to food. Depletion of populations of intestinal bacteria has been associated with the increasing prevalence of food allergy. Kemter et al. show that AhR ligands and flagella from commensal Clostridia regulate intestinal barrier permeability to limit allergen access to the systemic circulation and prevent allergic responses to food.
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影响因子：
32.4
作者：
Hou, Baidong;Reizis, Boris;DeFranco, Anthony L.
通讯作者：
DeFranco, Anthony L.
DOI：
10.1084/jem.20062648
发表时间：
2007-07-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Caton ML;Smith-Raska MR;Reizis B
通讯作者：
Reizis B
影响因子：
4.4
作者：
He, YW;Beers, C;Bevan, MJ
通讯作者：
Bevan, MJ
影响因子：
32.4
作者：
Chun, Eunyoung;Lavoie, Sydney;Garrett, Wendy S.
通讯作者：
Garrett, Wendy S.
影响因子：
24.5
作者：
Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
通讯作者：
Delzenne NM