Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell culture
Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell culture
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DOI：
10.1016/s0960-894x(97)00368-5
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发表时间：
1997-08-19
影响因子：
2.7
通讯作者：
Holwerda, BC
中科院分区：
文献类型：
--
作者：
Abood, NA;Schretzman, LA;Holwerda, BC
制备了一系列 2-氨基取代的苯并恶嗪酮，在体外有效抑制人巨细胞病毒蛋白酶。所选化合物在细胞培养物中表现出抗病毒活性、相对于胰凝乳蛋白酶和弹性蛋白酶的选择性以及在人血浆中水解的稳定性。 (C) 1997 爱思唯尔科学有限公司。
A series of 2-amino substituted benzoxazinones were prepared that potently inhibit human cytomegalovirus protease in vitro. Selected compounds demonstrate antiviral activity in cell culture, selectivity relative to chymotrypsin and elastase and stability with respect to hydrolysis in human plasma. (C) 1997 Elsevier Science Ltd.