Active transport of cytoophidia in Schizosaccharomyces pombe.
Active transport of cytoophidia in Schizosaccharomyces pombe.
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粟酒裂殖酵母中胞虫的主动运输
DOI：
10.1096/fj.201800045rr
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Liu JL
中科院分区：
文献类型：
--
作者：
Li H;Ye F;Ren JY;Wang PY;Du LL;Liu JL
The metabolic enzyme cytidine triphosphate synthase has recently been found to form micrometer-sized filamentous structures termed cytoophidia, which are evolutionarily conserved across prokaryotes and eukaryotes. The cytoophidium represents a novel type of membraneless organelle and behaves dynamically inside the cell. The question of how cytoophidia transport is mediated, however, remains unanswered. For the first time, we detected in this study the active transport of cytoophidia, taking advantage of the fission yeast Schizosaccharomyces pombe as an excellent model for studying membraneless organelles. We demonstrated that actin filaments, not microtubules, are responsible for this transport. Furthermore, we determined that Myo52, a type of myosin V, is required for the active transport of cytoophidia. These results reveal the major players critical to the dynamics of cytoophidia and extend our understanding of intracellular transport of membraneless organelles.—Li, H., Ye, F., Ren, J.-Y., Wang, P.-Y., Du, L.-L., Liu, J.-L. Active transport of cytoophidia in Schizosaccharomyces pombe.
