Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas
Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas
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DOI：
10.1007/s00428-009-0772-4
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发表时间：
2009-05
期刊：
影响因子：
3.5
通讯作者：
Yihua Pei;J. Kano;T. Iijima;Y. Morishita;Y. Inadome;M. Noguchi
中科院分区：
文献类型：
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作者：
Yihua Pei;J. Kano;T. Iijima;Y. Morishita;Y. Inadome;M. Noguchi
Dickkopf 3 (Dkk3) 是一种在肝发生早期阶段表达的蛋白质。在这项研究中，我们检查了 Dkk3 是否与肝母细胞瘤 (HBL) 和肝细胞癌 (HCC) 的过早或去分化性质相关。结果表明，Dkk3 在 HBL 和 HCC 中过表达，并且前者的表达频率高于后者，这与大多数 HBL 显示胚胎或胎儿肝组织学的事实一致，而 Dkk3 表达与临床数据或组织学之间没有明显的关系。所有 HBL 均表达 Dkk3、甲胎蛋白 (AFP) 或两种蛋白，这表明与 AFP 类似，Dkk3 是检测多种 HBL 的另一种潜在有用的生物标志物。此外，Dkk3和AFP在肿瘤中相互表达。这些结果表明，Dkk3 可能与 HBL 和 HCC 的过早或去分化性质有关，而 AFP 可能与分化程度更高的性质有关。因此，Dkk3 和 AFP 的评估可能有助于肝脏肿瘤的诊断。
Dickkopf 3 (Dkk3) is a protein expressed at a very early stage of hepatogenesis. In this study, we examined whether Dkk3 was related to a premature or dedifferentiated nature in hepatoblastomas (HBLs) and hepatocellular carcinomas (HCCs). It was demonstrated that Dkk3 was overexpressed in HBLs and HCCs and that its expression was more frequent in the former than in the latter, being consistent with the fact that most HBLs show an embryonal or fetal hepatic histology, whereas there was no distinct relationship between Dkk3 expression and clinical data or histology. All of the HBLs expressed Dkk3, alpha-fetoprotein (AFP), or both proteins, suggesting that, similar to AFP, Dkk3 is another potentially useful biomarker detecting a wide range of HBLs. Furthermore, Dkk3 and AFP were expressed reciprocally in the tumors. These results suggest that Dkk3 may be related to the premature or dedifferentiated nature of HBLs and HCCs, whereas AFP may be related to a more differentiated nature. Thus, assessment of Dkk3 and AFP may be useful in the diagnosis of hepatic tumors.