Exploring the role of the posterior middle temporal gyrus in semantic cognition: Integration of anterior temporal lobe with executive processes.
Exploring the role of the posterior middle temporal gyrus in semantic cognition: Integration of anterior temporal lobe with executive processes.
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DOI：
10.1016/j.neuroimage.2016.05.051
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发表时间：
2016-08-15
期刊：
影响因子：
5.7
通讯作者：
Jefferies E
中科院分区：
文献类型：
--
作者：
Davey J;Thompson HE;Hallam G;Karapanagiotidis T;Murphy C;De Caso I;Krieger-Redwood K;Bernhardt BC;Smallwood J;Jefferies E
理解我们周围的世界取决于有选择地检索与我们当前目标或背景相关的信息。然而，目前还不清楚选择性语义检索是否完全依赖于一般的控制机制，在要求非语义任务，或相反，专门用于控制意义的系统。一个假设是，左后颞中回（pMTG）是重要的语义（非语义）信息的控制检索，但这种观点仍然存在争议，因为平行的文献链接到事件和关系语义这个网站。在一项功能性神经影像学研究中，我们通过最近的荟萃分析证明，pMTG中涉及语义控制的一个区域在（i）语义关联超过大小判断和（ii）动作超过颜色特征匹配的联合中被激活。在这种情况下，同一个区域显示出与额下回的功能耦合，额下回是语义控制的另一个关键部位。结构和功能的连接性分析表明，这个网站是在自动语义处理（默认模式网络）和执行要求高的任务（多需求网络）招募网络的连接。此外，在这两个任务和无任务的情况下，pMTG表现出的功能特性，更类似于腹侧部分的下额叶皮层，牵连在控制语义检索，比更多的背侧下额叶沟，牵连在域一般控制。最后，pMTG区域在休息时与涉及控制要求语义任务的其他区域（包括额下回和顶内沟）在功能上相关。我们认为，pMTG可能发挥了至关重要的作用，在一个大规模的网络，允许集成的自动检索的默认模式网络与执行要求的目标导向的认知，这可以支持我们的能力，理解行动和非主导的语义关联，允许语义检索的“形状”，以适应任务或上下文。后颞中回支持语义控制和事件语义。pMTG是默认模式和多需求网络的连接点。它连接着前颞区和前额叶区，以进行表征和控制。pMTG在任务期间和休息时与额下回连接。这些网站形成了一个语义控制网络不同于执行控制。
Making sense of the world around us depends upon selectively retrieving information relevant to our current goal or context. However, it is unclear whether selective semantic retrieval relies exclusively on general control mechanisms recruited in demanding non-semantic tasks, or instead on systems specialised for the control of meaning. One hypothesis is that the left posterior middle temporal gyrus (pMTG) is important in the controlled retrieval of semantic (not non-semantic) information; however this view remains controversial since a parallel literature links this site to event and relational semantics. In a functional neuroimaging study, we demonstrated that an area of pMTG implicated in semantic control by a recent meta-analysis was activated in a conjunction of (i) semantic association over size judgements and (ii) action over colour feature matching. Under these circumstances the same region showed functional coupling with the inferior frontal gyrus — another crucial site for semantic control. Structural and functional connectivity analyses demonstrated that this site is at the nexus of networks recruited in automatic semantic processing (the default mode network) and executively demanding tasks (the multiple-demand network). Moreover, in both task and task-free contexts, pMTG exhibited functional properties that were more similar to ventral parts of inferior frontal cortex, implicated in controlled semantic retrieval, than more dorsal inferior frontal sulcus, implicated in domain-general control. Finally, the pMTG region was functionally correlated at rest with other regions implicated in control-demanding semantic tasks, including inferior frontal gyrus and intraparietal sulcus. We suggest that pMTG may play a crucial role within a large-scale network that allows the integration of automatic retrieval in the default mode network with executively-demanding goal-oriented cognition, and that this could support our ability to understand actions and non-dominant semantic associations, allowing semantic retrieval to be ‘shaped’ to suit a task or context. Posterior middle temporal gyrus supports semantic control and event semantics. pMTG is at nexus of the default mode and multiple-demand networks. It links anterior temporal and prefrontal regions for representation and control. pMTG connects with inferior frontal gyrus during tasks and at rest. These sites form a semantic control network distinct from executive control.