PAMPs and DAMPs as triggers for DIC.
PAMPs and DAMPs as triggers for DIC.
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DOI：
10.1186/s40560-014-0065-0
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发表时间：
2014
影响因子：
7.1
通讯作者：
Ito T
中科院分区：
文献类型：
--
作者：
Ito T
血栓形成通常被认为是有害的，因为它损害了器官的血液供应。然而，最近的研究表明，在某些情况下，血栓形成在抵抗入侵病原体的早期免疫防御中起着重要的生理作用。血栓形成的这种防御作用现在被称为免疫血栓形成。活化的单核细胞和中性粒细胞是免疫血栓形成的两种主要诱导物。当单核细胞和中性粒细胞检测到病原体相关分子模式（PAMP）和损伤相关分子模式（DAMP）时，它们被激活。PAMP和DAMP的检测触发单核细胞上的组织因子表达和中性粒细胞释放中性粒细胞胞外陷阱（NET），促进免疫血栓形成。虽然组织因子介导和NET介导的免疫血栓形成在早期宿主防御细菌传播中发挥作用，但不受控制的免疫血栓形成可能导致弥散性血管内凝血。
Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis. Activated monocytes and neutrophils are two major inducers of immunothrombosis. Monocytes and neutrophils are activated when they detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Detection of PAMPs and DAMPs triggers tissue factor expression on monocytes and neutrophil extracellular trap (NET) release by neutrophils, promoting immunothrombosis. Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation.