IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions
IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions
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DOI：
10.1016/j.canlet.2008.03.030
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发表时间：
2008-09-08
期刊：
影响因子：
9.7
通讯作者：
Inoue, Masahiro
中科院分区：
文献类型：
--
作者：
Koga, Takumi;Endo, Hiroko;Inoue, Masahiro
在缺氧条件下，癌细胞和正常细胞的蛋白质合成通常都会受到抑制。在耐低氧张力的人胰腺癌AsPC-1细胞中，缺氧(1% O(2))下第4天的蛋白质合成约为常氧下的20%。尽管蛋白质合成普遍减少，但一些蛋白质的分泌实际上增加了；其中两种蛋白质是胰岛素样生长因子结合蛋白-1 (IGFBP-1) 和 IGFBP-3。缺氧还诱导多种 IGFBP 的转录。 IGFBP 有助于减少 IGF 信号传导，并有助于癌细胞在低氧张力条件下存活。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
Protein synthesis in general is suppressed under hypoxic conditions in both cancer cells and normal cells. In human pancreatic cancer AsPC-1 cells, which are resistant to low oxygen tension, protein synthesis at day 4 under hypoxia (1% O(2)) was about 20% of that under normoxia. Secretion of some proteins actually increased in spite of a general reduction in protein synthesis; two of these proteins were insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3. Hypoxia also induced transcription of multiple IGFBPs. The IGFBPs contributed to reduced IGF signaling and to the survival of cancer cells under conditions of low oxygen tension. (C) 2008 Elsevier Ireland Ltd. All rights reserved.