Decreased prefrontal oxygenation elicited by stimulation of limb mechanosensitive afferents during cycling exercise
Decreased prefrontal oxygenation elicited by stimulation of limb mechanosensitive afferents during cycling exercise
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DOI：
10.1152/ajpregu.00454.2017
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发表时间：
2018-08-01
影响因子：
2.8
通讯作者：
Matsukawa, Kanji
中科院分区：
文献类型：
--
作者：
Asahara, Ryota;Matsukawa, Kanji
我们的实验室报告使用近红外光谱，肢体机械传入的反馈可能会降低前额叶氧合血红蛋白浓度（Oxy-Hb）在后期的自愿和被动循环。为了检验这一假设，即减少的前额叶皮层的氧合血红蛋白将增加取决于肢体机械传入输入的程度，前额叶的氧合血红蛋白反应进行了测量，在电机驱动的单腿和双腿被动骑自行车1分钟，在各种革命的踏板运动在19个科目。此外，我们研究了计算的组织氧合指数（TOI）是否在被动循环过程中下降的Oxy-Hb，同时评估颅外皮肤组织和颈总动脉和颈内动脉（CCA和伊卡）的血流量与激光和超声多普勒血流仪。分钟通气量和心输出量增加，外周阻力下降，在被动循环，这取决于两个旋转的踏板运动和肢体的数量，而平均动脉血压没有变化。被动循环没有改变潮气末CO2，表明没有低碳酸血症的变化。前额叶Oxy-Hb在被动骑车过程中降低，与踏板运动的转数成正比，而与骑车肢体的数目无关。此外，前额TOI下降，在被动循环Oxy-Hb没有，而前额皮肤组织，CCA和伊卡的血流量没有显着变化。因此，Oxy-Hb的减少反映了脑内血管系统的组织血流量减少，而不是脑外室。这是可能的反馈，从机械传入减少区域脑血流量的前额叶皮层有关的革命踏板运动。
Our laboratory reported using near-infrared spectroscopy that feedback from limb mechanoafferents may decrease prefrontal oxygenated-hemoglobin concentration (Oxy-Hb) during the late period of voluntary and passive cycling. To test the hypothesis that the decreased Oxy-Hb of the prefrontal cortex would be augmented depending on the extent of limb mechanoafferent input, the prefrontal Oxy-Hb response was measured during motor-driven one-and two-legged passive cycling for 1 min at various revolutions of pedal movement in 19 subjects. Furthermore, we examined whether calculated tissue oxygenation index (TOI) decreased during passive cycling as the Oxy-Hb did, simultaneously assessing blood flows of extracranial cutaneous tissue and the common and internal carotid arteries (CCA and ICA) with laser and ultrasound Doppler flowmetry. Minute ventilation and cardiac output increased and peripheral resistance decreased during passive cycling, depending on both revolutions of pedal movement and number of limbs, whereas mean arterial blood pressure did not change. Passive cycling did not change end-tidal CO2, suggesting absence of a hypocapnic change. Prefrontal Oxy-Hb decreased during passive cycling, being in proportion to revolution of pedal movement but not number of cycling limbs. In addition, prefrontal TOI decreased during passive cycling as Oxy-Hb did, whereas blood flows of forehead cutaneous tissue, CCA, and ICA did not change significantly. Thus, a decrease in Oxy-Hb reflected a decrease in tissue blood flow of the intracerebral vasculature but not the extracerebral compartment. It is likely that feedback from mechanoafferents decreased regional cerebral blood flow of the prefrontal cortex in relation to the revolutions of pedal movement.