Evolving understanding of the CLL genome.
Evolving understanding of the CLL genome.
复制标题
DOI：
10.1053/j.seminhematol.2014.05.004
复制
发表时间：
2014-07
影响因子：
3.6
通讯作者：
Wu CJ
中科院分区：
文献类型：
--
作者：
Gruber M;Wu CJ
在过去的几年里，大规模平行测序技术已经以高分辨率揭示了慢性淋巴细胞白血病（CLL）中巨大的遗传和表观遗传异质性。我们已经了解了分子结构不仅在受影响的个体之间，而且在样品内和随着时间的推移是如何不同的。这些见解促进了我们对CLL病理生物学的理解，并指出了疾病发展和进展中的关键信号通路。已经确定了几个关键的驱动改变，这有助于改善预后模式，但也激发了新的治疗策略的发展。技术的不断进步有望进一步阐明CLL的分子基础，预计这些知识将有助于我们理解和解决CLL患者临床过程中巨大变异性所带来的临床挑战。
Over the past few years, massively parallel sequencing technologies have revealed with high resolution the tremendous genetic and epigenetic heterogeneity in chronic lymphocytic leukemia (CLL). We have learned how the molecular architecture differs not only between affected individuals but also within samples and over time. These insights have catalyzed our understanding of the pathobiology of CLL and point to critical signaling pathways in the development and progression of the disease. Several key driver alterations have been identified, which serve to refine prognostic schemata but also inspire the development of new therapeutic strategies. Ongoing advances in technology promise to further elucidate the molecular basis of CLL, and this knowledge is anticipated to aid us in understanding and addressing the clinical challenge presented by the vast variability in the clinical course of patients with CLL.
登录
查看更多内容
影响因子：
64.8
作者：
Greaves, Mel;Maley, Carlo C.
通讯作者：
Maley, Carlo C.
影响因子：
4.5
作者：
Garding A;Bhattacharya N;Claus R;Ruppel M;Tschuch C;Filarsky K;Idler I;Zucknick M;Caudron-Herger M;Oakes C;Fleig V;Keklikoglou I;Allegra D;Serra L;Thakurela S;Tiwari V;Weichenhan D;Benner A;Radlwimmer B;Zentgraf H;Wiemann S;Rippe K;Plass C;Döhner H;Lichter P;Stilgenbauer S;Mertens D
通讯作者：
Mertens D
影响因子：
11.4
作者：
Cahill, N.;Bergh, A-C;Rosenquist, R.
通讯作者：
Rosenquist, R.
影响因子：
20.3
作者：
Kanduri, Meena;Cahill, Nicola;Rosenquist, Richard
通讯作者：
Rosenquist, Richard
DOI：
10.1084/jem.20110921
发表时间：
2011-07-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fabbri G;Rasi S;Rossi D;Trifonov V;Khiabanian H;Ma J;Grunn A;Fangazio M;Capello D;Monti S;Cresta S;Gargiulo E;Forconi F;Guarini A;Arcaini L;Paulli M;Laurenti L;Larocca LM;Marasca R;Gattei V;Oscier D;Bertoni F;Mullighan CG;Foá R;Pasqualucci L;Rabadan R;Dalla-Favera R;Gaidano G
通讯作者：
Gaidano G