PROBABILITY OF RADIATION-INDUCED COMPLICATIONS FOR NORMAL-TISSUES WITH PARALLEL ARCHITECTURE SUBJECT TO NONUNIFORM IRRADIATION
PROBABILITY OF RADIATION-INDUCED COMPLICATIONS FOR NORMAL-TISSUES WITH PARALLEL ARCHITECTURE SUBJECT TO NONUNIFORM IRRADIATION
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DOI：
10.1118/1.597056
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发表时间：
1993-05-01
期刊：
影响因子：
3.8
通讯作者：
YORKE, ED
中科院分区：
文献类型：
--
作者：
JACKSON, A;KUTCHER, GJ;YORKE, ED
建立了一个基于生物学的模型，用于预测非均匀辐照器官（如肺或肾）中辐射诱导的正常组织并发症概率（NTCP）。该器官被认为是由独立的功能亚单位（FSU）组织与平行的架构，并假设只有当足够大的FSU（“功能储备”）被破坏的复杂性。导出了NTCP的一般表达式，以及FSU辐射损伤均值和标准差的简单表达式。它表明，这些结果的不均匀照射再现的系列和肿瘤控制模型时，功能储备由一个或所有的FSU，分别。当FSU的数量很大时，具有相同特征的器官的剂量反应非常陡峭。由于临床剂量反应曲线可能会出现不同的功能储备和放射敏感性的人群，我们推导出的NTCP的表达式，将这种变化的非均匀照射的器官。
A biologically based model is developed to predict radiation-induced normal tissue complication probability (NTCP) in inhomogeneously irradiated organs such as the lung or the kidney. The organ is assumed to be composed of independent functional subunits (FSUs) organized with a parallel architecture and it is assumed that the complication is produced only if a sufficiently large number of FSUs (the ''functional reserve'') are destroyed. A general expression for NTCP is derived, as wen as simple expressions for the mean and standard deviation of the radiation damage to the FSUs. It is demonstrated that these results for inhomogeneous irradiation reproduce those of the serial and tumor control models when the functional reserve consists of one or all of the FSUs, respectively. When the number of FSUs is large, the dose response for organs with identical characteristics is very steep. Since clinical dose-response curves may arise from populations with varying functional reserves and radiosensitivities, we derive expressions for the NTCP for inhomogeneously irradiated organs that incorporate such variations.