Fabrication of flexible microelectrode arrays integrated with microfluidic channels for stable neural interfaces
Fabrication of flexible microelectrode arrays integrated with microfluidic channels for stable neural interfaces
复制标题
制造与微流体通道集成的柔性微电极阵列，用于稳定的神经接口
DOI：
10.1016/j.sna.2013.04.005
复制
发表时间：
2013-08-01
影响因子：
4.6
通讯作者：
Xu, Yuansen
中科院分区：
文献类型：
--
作者：
Gao, Kunpeng;Li, Gang;Xu, Yuansen
为了实现植入神经假体的长期有效性，我们开发了一种简单且低成本的制造工艺，用于集成微流体通道的柔性神经微电极，用于同时药物输送和多通道刺激。在这个过程中，一个传统的薄膜电极制造过程相结合的聚（二甲基硅氧烷）成型和键合技术。与目前的制造方法相比，该工艺显著降低了制造所需的成本和时间。通过光学显微镜、阻抗测量和扩散测试对微电极进行了表征。还进行了数值模拟，以证明通过微通道的药物释放的流体动力学，并评估其输送速率和效率方面的设备的性能。结果表明，药物释放速率在前两天约为每日总量的20%，在接下来的10天中每天约为每日总量的4%。释放过程可能持续2周以上。结果表明，该缓释片具有缓释效果好、载药量高的特点。(c)2013爱思唯尔有限公司版权所有。
To achieve long-term effectiveness of implanted neural prostheses, we developed a simple and low-cost fabrication process for flexible neural microelectrodes integrated with microfluidic channels for simultaneous drug delivery and multi-channel stimulation. In this process, a conventional thin-film electrode fabrication procedure is combined with poly(dimethylsiloxane) molding and a bonding technique. Compared with the current fabrication method, this process significantly reduces the cost and time needed for fabrication. The microelectrodes were characterized by optical microscopy, impedance measurements and diffusion tests. A numerical simulation was also performed to demonstrate the fluid dynamics of drug release through the microchannels and evaluate the device's performance in terms of its delivery rate and efficiency. The results show that the drug release rate is about 20% of the total amount per day in the first two days and about 4% of the total amount per day in each of the next 10 days. The release process can last more than 2 weeks. The result meets the requirement for long-term release and sufficient drug loading. (c) 2013 Elsevier B.V. All rights reserved.