Ventilation imaging of the lung: Comparison of hyperpolarized helium-3 MR imaging with Xe-133 scintigraphy
Ventilation imaging of the lung: Comparison of hyperpolarized helium-3 MR imaging with Xe-133 scintigraphy
复制标题
DOI：
10.1016/j.acra.2004.04.001
复制
发表时间：
2004-07-01
影响因子：
4.8
通讯作者：
de Lange, EE
中科院分区：
文献类型：
--
作者：
Altes, TA;Rehm, PK;de Lange, EE
理由和目标。比较肺的超极化氦-3（HHe）磁共振成像（MRI）与标准的核素133肺通气造影。我们对15名接受HHe MRI和133肺通气成像的受试者进行了回顾性分析。在单次吸入HHe气体后获得冠状面MRI切片，并在连续呼吸133气体期间进行标准后平面肺通气造影。将每例患者的第一次呼吸心电图与由单个MR图像和单个氦-3 MR图像的总和组成的复合MR图像进行比较。比较两种成像模式的通气缺陷的大小、明显性以及存在和位置的一致性。分别对四个肺象限进行评估。将复合HHe MR图像与133 MRI图像进行比较，67%（40/60）、63%（38/60）和62%（37/60）象限的通气缺损大小、显著性和一致性分别相同。将单个HHe MR图像切片与MRI-133通气扫描进行比较，27%（16/60）的象限中通气缺陷之间存在一致性。在62%（37/60）的象限中，单个HHe MR图像显示更多的缺损。复合HHe MR图像与第一次呼吸Xe-133闪烁照相图像之间存在良好的一致性，支持了广泛持有的假设，即HHe MRI可能描绘了第一次呼吸肺通气。
Rationale and Objectives. To compare hyperpolarized helium-3 (HHe) magnetic resonance imaging (MRI) of the lung with standard Xe-133 lung ventilation scintigraphy.Materials and Methods. We performed a retrospective review of 15 subjects who underwent HHe MRI and Xe-133 lung ventilation imaging. Coronal MRI sections were acquired after a single inhalation of HHe gas, and standard posterior planar lung ventilation scintigraphy was performed during continuous breathing of Xe-133 gas. The first breath scintigram of each patient was compared with a composite MR image composed of the sum of the individual MR images and with the individual helium-3 MR images. Ventilation defects on the two imaging modalities were compared for size, conspicuity, and concordance in presence and location. Assessment was done separately for each of four lung quadrants.Results. Comparing the composite HHe MR images with Xe-133 scintigraphy, ventilation defect size, conspicuity and concordance were the same in 67% (40/60), 63% (38/60), and 62% (37/60) quadrants, respectively. Comparing the individual HHe MR image sections with the Xe-133 ventilation scan, there was concordance between the ventilation defects in 27% (16/60) of quadrants. More defects were identified on the individual HHe MR images in 62% (37/60) of quadrants.Conclusion. There was good agreement between composite HHe MR image and first breath Xe-133 scintigraphic images, supporting the widely held assumption that HHe MRI likely depicts first breath lung ventilation.