Compared properties of central and peripheral binding sites for phencyclidine.
Compared properties of central and peripheral binding sites for phencyclidine.
复制标题
比较苯环己哌啶的中心和外周结合位点的特性。
DOI：
10.1016/0014-2999(80)90065-5
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发表时间：
1980
影响因子：
5
通讯作者：
Michel Lazdunski
中科院分区：
文献类型：
--
作者：
Jean;J. Vignon;B. Kartalovski;Michel Lazdunski
苯环己哌啶及其衍生物与大鼠大脑和周围器官特异性且可逆地结合。脑、肺、肾、心脏和肝脏的结合特征不同。苯环己哌啶对脑受体的亲和力而非外周器官的亲和力与旋转棒试验中测得的苯环己哌啶的药理活性相关。
Phencyclidine and its derivatives bind specifically and reversibly to rat brain and peripheral organs. Binding characteristics are different in brain, lung, kidney, heart and liver. Affinities of phencyclidines for the brain receptor but not those for peripheral organs are correlated with the pharmacological activities of phencyclidines as measured in the rotarod test.