Nonalcoholic fatty liver disease is associated with carotid atherosclerosis -: A case-control study
Nonalcoholic fatty liver disease is associated with carotid atherosclerosis -: A case-control study
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DOI：
10.1161/01.atv.0000160613.57985.18
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发表时间：
2005-05-01
影响因子：
8.7
通讯作者：
Ros, E
中科院分区：
文献类型：
--
作者：
Brea, A;Mosquera, D;Ros, E
目的 - 非酒精性脂肪肝病 (NAFLD) 经常与肥胖、糖尿病和血脂异常共存。我们通过颈动脉超声测量，检查 NAFLD 是否与动脉粥样硬化相关。方法和结果 - 对 40 名经超声诊断为原发性 NAFLD 的患者和 40 名匹配的对照人群进行颈动脉粥样硬化和心血管危险因素评估。 NAFLD 患者中代谢综合征及其所有个体特征（包括 C 反应蛋白升高）的发生率显着高于对照组（P < 0.005）。 NAFLD 患者的颈动脉粥样硬化程度高于对照组，平均内膜中层厚度 (IMT) 为 0.70 +/- 0.20 mm 和 0.54 +/- 0.13 mm ( P < 0.0001)，斑块患病率分别为 50% 和 25% ( P = 0.021)。通过多变量分析，年龄较大（优势比[OR]，2.5/10年；95% CI，1.4至4.4；P = 0.002）、NAFLD的存在（OR，8.4；95% CI，2.49至29.4；P = 0.001）以及血清铁蛋白升高（OR，3.1；95% CI， 1.2 至 7.9；P = 0.016) 是增加的独立预测因素 IMT.结论 - NAFLD 患者表现出一系列代谢综合征和晚期颈动脉粥样硬化的危险因素。 NAFLD 似乎是代谢综合征的一个特征，腹部超声检测应警惕心血管风险增加的存在。
Objective - Nonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia. We examined whether NAFLD was associated with atherosclerosis, as measured by ultrasound in the carotid arteries.Methods and Results - Carotid atherosclerosis and cardiovascular risk factors were assessed in 40 patients with an ultrasound diagnosis of primary NAFLD and 40 matched population controls. The metabolic syndrome and all its individual traits, including elevated C-reactive protein, were significantly ( P < 0.005) more frequent in NAFLD patients than in control subjects. Patients with NAFLD showed more carotid atherosclerosis than controls, with mean intima-media thickness (IMT) of 0.70 +/- 0.20 mm and 0.54 +/- 0.13 mm ( P < 0.0001) and plaque prevalence of 50% and 25% ( P = 0.021), respectively. By multivariate analysis, older age ( odds ratio [ OR], 2.5 per 10 years; 95% CI, 1.4 to 4.4; P = 0.002), the presence of NAFLD ( OR, 8.4; 95% CI, 2.49 to 29.4; P = 0.001), and elevated serum ferritin ( OR, 3.1; 95% CI, 1.2 to 7.9; P = 0.016) were independent predictors of an increased IMT.Conclusions - Patients with NAFLD show a cluster of risk factors of the metabolic syndrome and advanced carotid atherosclerosis. NAFLD appears to be a feature of the metabolic syndrome, and its detection on abdominal ultrasound should alert to the existence of an increased cardiovascular risk.