EFFECTS OF PROPRANOLOL ON COLONIC PRESSURE IN PATIENTS WITH IRRITABLE BOWEL SYNDROME
EFFECTS OF PROPRANOLOL ON COLONIC PRESSURE IN PATIENTS WITH IRRITABLE BOWEL SYNDROME
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DOI：
10.3109/00365528109181022
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发表时间：
1981-01-01
影响因子：
1.9
通讯作者：
DOTEVALL, G
中科院分区：
文献类型：
--
作者：
ABRAHAMSSON, H;DOTEVALL, G
研究了普萘洛尔对10例肠易激综合征患者结肠运动的影响。在距肛门15-18 cm处测压记录结肠运动，总收缩活动（kPa[千帕斯卡].次）。最小)同时集成。休息后，分别在生理盐水（对照期）和普萘洛尔（5mg）静脉注射后30 min记录结肠运动。10例患者中有9例在普萘洛尔后结肠运动增强。1例患者无变化。在对照期，总收缩活性为7.7 +-。1.8（平均值的标准误差）kPa。最小(58 .+-。14毫米汞柱。心得安后升高至14.2 +-。2.3 kPa。最小(107 .+-。17毫米汞柱。分钟)。差异有统计学意义（P < 0.01）。服用心得安后，结肠压力波有规律地出现的时间更长，幅度也比对照组活动时高。2例患者观察到基础压延长升高并叠加压力波。肾上腺素的度量。-阻滞剂因此增强人的结肠活力。这一结果或许可以解释接受.beta治疗的患者出现的腹部症状，如疼痛和排便习惯的改变。利用药物。
The effect of propranolol on colonic motility was studied in 10 patients with irritable bowel syndrome. Colonic motility was recorded by pressure measurement 15-18 cm from the anus and total contractile activity (kPa [kilopascal] .times. min) simultaneously integrated. After rest, motility was recorded for 30 min after injection of saline (control period) and after injection of 5 mg propranolol i.v. Administration of propranolol was followed by an increase in colonic motility in 9 of the 10 patients. In 1 patient no change was observed. During the control period, total contractile activity was 7.7 .+-. 1.8 (standard error of the mean) kPa .times. min (58 .+-. 14 mm Hg .times. min), increasing after propranolol to 14.2 .+-. 2.3 kPa .times. min (107 .+-. 17 mm Hg .times. min). The difference was significant (P < 0.01). After propranolol, the colonic pressure waves regularly appeared for longer periods of time and had higher amplitudes than during control activity. Prolonged elevation of basal pressure with superimposed pressure waves was observed in 2 patients. Adrenergic .beta.-blocking agents thus enhance colonic motility in man. The results may explain abdominal symptoms, such as pain and change in bowel habits appearing in patients treated with .beta.-blocking drugs.