Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system
Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system
复制标题
DOI：
10.1182/blood.v95.2.719
复制
发表时间：
2000-01-15
期刊：
影响因子：
20.3
通讯作者：
Gross, HJ
中科院分区：
文献类型：
--
作者：
Reuter, T;Herterich, S;Gross, HJ
在至少8个范可尼贫血（Fanconi anemia， FA）基因中，已有3个基因被克隆（FANCA、FANCC、FANCG），但其功能尚不清楚。利用酵母2杂交系统和全长cDNA，作者发现FANCA和FANCG蛋白之间存在强相互作用。他们还获得了FANCA和FANCC之间弱相互作用的证据，FANCA和FANCC都没有被发现与自身相互作用，这些结果支持了FA基因产物之间功能关联的概念。
Three of at least 8 Fanconi anemia (FA) genes have been cloned (FANCA, FANCC, FANCG), but their functions remain unknown, Using the yeast 2-hybrid system and full-length cDNA, the authors found a strong interaction between FANCA and FANCG proteins. They also obtained evidence for a weak interaction between FANCA and FANCC, Neither FANCA nor FANCC was found to interact with itself, These results support the notion of a functional association between the FA gene products.