A new tool to evaluate the impact of chronic urticaria on quality of life:: chronic urticaria quality of life questionnaire (CU-Q2oL)
A new tool to evaluate the impact of chronic urticaria on quality of life:: chronic urticaria quality of life questionnaire (CU-Q2oL)
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DOI：
10.1111/j.1398-9995.2005.00833.x
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发表时间：
2005-08-01
期刊：
影响因子：
12.4
通讯作者：
Canonica, GW
中科院分区：
文献类型：
--
作者：
Baiardini, I;Pasquali, M;Canonica, GW
背景：慢性荨麻疹患者的健康相关生活质量通过通用仪器或针对皮肤病设计的问卷进行评估。从患者的角度评估慢性荨麻疹的影响，目前还没有疾病特异性的工具。目的：我们的研究目的是开发和验证一种专门用于评估慢性荨麻疹患者生活质量的新问卷（慢性荨麻疹生活质量问卷- CU-Q(2)oL）方法：在CU-Q(2)oL的开发阶段，编制了37个项目的初始清单，并对80例慢性荨麻疹患者进行了问卷调查；选出23个最重要的项目，并将其转换为按照李克特量表（Likert scale）的五个步骤评估答案的问题。验证过程涉及125例患者（86例F和39例M）（年龄42.17±9.24岁）。结果：经统计分析，CU-Q(2)oL的提取因子具有六维结构和良好的内部一致性：瘙痒（0.79）、肿胀（0.65）、对生活活动的影响（0.83）、睡眠问题（0.77）、外观（0.83）和限制（0.74）。在稳定条件下，CU-Q(2)oL具有良好的信度，在0.64 ~ 0.92之间。完成了对临床变化的反应。讨论：这些结果提供了证据，表明CU- q (2)oL具有足够的特异性，可以作为检测CU对主观幸福感的相对负担的有效工具，并且可以在考虑患者观点的情况下获得CU影响和治疗的整体评估。CU-Q(2)oL易于快速填充，患者接受度高。
Background: Health-related quality of Life in patients with chronic urticaria is evaluated by mean of generic instruments or questionnaire designed for skin diseases. No disease-specific tool is now available for the assessment of chronic urticaria impact from patients' viewpoint.Objective: The aim of our study is to develop and validate a new questionnaire specifically designed for the assessment of quality of life in chronic urticaria (Chronic Urticaria Quality of Life Questionnaire - CU-Q(2)oL)Methods: In the development phase of CU-Q(2)oL an initial list of items of 37 items was compiled and given to 80 patients with chronic urticaria; the 23 most significant items were selected and converted into questions evaluating the answers on a Likert scale of five steps. The validation procedure involved 125 patients (86 F and 39 M) (age 42.17 +/- 9.24 years).Results: Following a statistical analysis, CU-Q(2)oL showed a six-dimensional structure and good levels of internal consistency for the extracted factors: Pruritus (0.79), Swelling (0.65), Impact on life activities (0.83), Sleep problems (0.77), Looks (0.83) and Limits (0.74). In stable conditions CU-Q(2)oL showed a good reliability, ranged between 0.64 and 0.92. Responsiveness to clinical changes was accomplished.Discussion: These results provide evidence that CU-Q(2)oL has specificity enough for being a valid tool for detecting the relative burden of CU on subjective wellbeing, and for obtaining a global evaluation both of CU impact and of treatments, taking into account the patient's point of view. The CU-Q(2)oL was easily and quickly filled up and well accepted by the patients.