Activity-dependent constraints on catecholamine signaling.
Activity-dependent constraints on catecholamine signaling.
复制标题
儿茶酚胺信号传导的活动依赖性限制。
DOI：
10.1101/2023.03.30.534970
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Bruchas,MichaelR
中科院分区：
文献类型：
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作者：
Li,Li;Rana,Akshay;Li,EstherM;Feng,Jiesi;Li,Yulong;Bruchas,MichaelR
Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activityin vivodepleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together, these findings provide a more complete understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling.
