Immune responsiveness in the neonatal period
Immune responsiveness in the neonatal period
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DOI：
10.1016/j.jcpa.2007.04.008
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发表时间：
2007-07-01
影响因子：
0.8
通讯作者：
Hu, K.
中科院分区：
文献类型：
--
作者：
Morein, B.;Blomqvist, G.;Hu, K.
妊娠的维持需要抑制母体免疫系统，该系统将自然地将发育中的胎儿识别为同种异体移植物，并试图通过建立Th1调节的细胞毒性免疫应答来破坏它。在妊娠期间，胎盘产生一系列可溶性因子，这些因子将母体免疫调节转向保护性Th2表型。这些因素也影响胎儿免疫系统的发育，所有新生儿最初的免疫环境都倾向于Th 2免疫。因此，新生儿期的疫苗接种必须克服母源性抗体的抑制作用和这种天然Th2调节环境的双重挑战。克服这些障碍的一种方法是通过使用佐剂系统，该系统可以将新生儿免疫应答重定向到适当的Th1调节的反应，该反应提供对感染性疾病的保护。在这篇综述中，实验中描述的病毒抗原纳入免疫刺激复合物（ISCOM）能够诱导免疫反应与平衡的Th1和Th2调节新生小鼠，证明了IgG亚类反应和细胞因子的性质，并诱导细胞毒性淋巴细胞。ISCOM佐剂疫苗能够在较大动物物种（包括牛、马和狗）的新生儿中诱导类似的保护性免疫。(c)2007爱思唯尔有限公司保留所有权利。
The maintenance of pregnancy requires suppression of the maternal immune system which would naturally recognize the developing fetus as an allograft and seek to destroy it by mounting a Th1 regulated Cytotoxic immune response. During pregnancy a range of soluble factors are produced by the placenta which switch maternal immune regulation towards a protective Th2 phenotype. These factors also influence the developing fetal immune system and all newborns initially have an immunological milieu skewed towards Th2 immunity. Vaccination during the neonatal period must therefore overcome the dual challenge of the inhibitory effect of maternally derived antibody and this natural Th2 regulatory environment. One means of overcoming these obstacles is by the use of adjuvant systems that can redirect the neonatal immune response towards an appropriate Th1 regulated reaction that affords protection from infectious disease. In this overview, experiments are described in which viral antigens incorporated into immune stimulatory complexes (ISCOMs) are able to induce immune responses with balanced Th1 and Th2 regulation in neonatal mice, as evidenced by the nature of the IgG subclass response and cytokine profile, and the induction of cytotoxic lymphocytes. ISCOM adjuvanted vaccines are able to induce similar protective immunity in the newborn of larger animal species including cattle, horses and dogs. (c) 2007 Elsevier Ltd. All rights reserved.