Author ' s personal copy The neurobiology of social attachment : A comparative approach to behavioral , neuroanatomical , and neurochemical studies ☆
Author ' s personal copy The neurobiology of social attachment : A comparative approach to behavioral , neuroanatomical , and neurochemical studies ☆
复制标题
DOI：
--
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
K. Young;Yan Liu;Zuoxin Wang
中科院分区：
文献类型：
--
作者：
K. Young;Yan Liu;Zuoxin Wang
在大多数情况下，作者被允许将他们的文章版本（例如以Word或Tex形式）发布到他们的个人网站或机构存储库。如果作者需要有关爱思唯尔存档和手稿政策的更多信息，请访问：a r t i c l e i n f o a B s t r a c t成年后社会关系的形成和维持是人类健康的重要组成部分。然而，对这种行为的潜在神经生物学研究却很少。Microtine啮齿动物提供了一个独特的比较动物模型，以探索负责配对键合及其相关行为的神经过程。最近，对一夫一妻制草原田鼠和其他相关物种的研究为社会依恋的神经解剖学、神经生物学和神经化学基础提供了新的见解。本文通过对田鼠类啮齿动物的自然历史和社会行为的研究，探讨田鼠类啮齿动物在比较研究中的作用。然后，我们将总结的数据涉及加压素，催产素，多巴胺在调节配对债券。最后，我们将讨论这些神经化学系统可能相互作用以介导这种复杂行为的方式。社会行为涉及个体之间的复杂互动，在整个动物王国中以不同程度表现出来。例如，交配和攻击性是表现出不同生活策略的物种所共有的，而成年人之间形成牢固的纽带和双亲照顾后代通常只表现在遵循一夫一妻制生活策略的物种身上。牢固的社会纽带的形成对个人福祉至关重要，对人类来说，是心理健康的重要组成部分。因此，无法做到这一点被用作各种心理障碍的诊断组成部分，包括自闭症，社交焦虑症和精神分裂症（Alfremar，2001）。对社会联系背后的神经生物学的研究可能会对这种疾病的原因和治疗提供深入的了解。尽管已经开发了各种动物模型来研究哺乳动物物种普遍存在的社会行为，包括交配，母性护理和攻击（Seay et al. Trainor，2007），交配对之间形成强有力的纽带，（配对键合），以及与这些键合相关的行为，如配偶守卫（选择性攻击）和父亲的照顾，已经研究不足，也许是由于缺乏适当的动物模型。这些行为在动物王国中相对罕见，在哺乳动物中只有3 - 5%的一夫一妻制物种表现出来（Kleiman，1977）。…
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a r t i c l e i n f o a b s t r a c t The formation and maintenance of social bonds in adulthood is an essential component of human health. However studies investigating the underlying neurobiology of such behaviors have been scarce. Microtine rodents offer a unique comparative animal model to explore the neural processes responsible for pair bonding and its associated behaviors. Studies using monogamous prairie voles and other related species have recently offered insight into the neuroanatomical, neurobiological, and neurochemical underpinnings of social attachment. In this review, we will discuss the utility of the microtine rodents in comparative studies by exploring their natural history and social behavior in the laboratory. We will then summarize the data implicating vasopressin, oxytocin, and dopamine in the regulation of pair bonding. Finally, we will discuss the ways in which these neurochemical systems may interact to mediate this complex behavior. Social behavior involves complex interactions between individuals and is displayed, in varying degrees, throughout the animal kingdom. Mating and aggression, for example, are common to species that display disparate life strategies, while the formation of strong bonds between adults and the bi-parental care of offspring are generally only displayed by species that follow monogamous life strategies. The formation of strong social bonds is essential for individual well-being, and in humans, is a critical component of mental health. As such, an inability to do so is used as a diagnostic component of various psychological disorders, including autism, social anxiety, and schizo-phrenia (Volkmar, 2001). Study of the neurobiology underlying social bonding may provide insight into the causes and treatment of such disorders. Although various animal models have been developed to study social behaviors ubiquitous to mammalian species, including mating, maternal care, and aggression (Seay et al. Trainor, 2007), the formation of strong bonds between mating pairs (pair bonding), and behaviors associated with these bonds, such as mate guarding (selective aggression) and paternal care, have been understudied, perhaps due to the lack of appropriate animal models. These behaviors are relatively uncommon in the animal kingdom, and in mammals are only displayed by the 3–5% of species that are monogamous (Kleiman, 1977). …