Relative effectiveness of influenza vaccines among the U.S. elderly, 2018-19.
Relative effectiveness of influenza vaccines among the U.S. elderly, 2018-19.
复制标题
2018-19 年美国老年人流感疫苗的相对有效性。
DOI：
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发表时间：
2020
影响因子：
6.4
通讯作者：
R. Forshee
中科院分区：
文献类型：
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作者：
H. Izurieta;Y. Chillarige;J. Kelman;Yuqin Wei;Yun Lu;Wenjie Xu;Michael Lu;D. Pratt;M. Wernecke;T. MaCurdy;R. Forshee
BACKGROUND
Studies among individuals ages ≥65 years have found a moderately higher relative vaccine effectiveness (RVE) for the high-dose (HD) influenza vaccine compared to standard-dose (SD) products for most seasons. Studies during the A(H3N2)-dominated 2017-18 season showed slightly higher RVE for the cell-cultured vaccine compared to SD egg-based vaccines. We investigated the RVE of influenza vaccines among Medicare beneficiaries ages ≥65 years during the 2018-19 season.
METHODS
Retrospective cohort study using inverse probability of treatment weighting and Poisson regression to evaluate RVE in preventing influenza hospital encounters.
RESULTS
Among 12,777,214 beneficiaries, the egg-based adjuvanted (RVE 7.7%, 95% CI: 3.9 to 11.4%) and high-dose (RVE 4.9%, 95% CI: 1.7 to 8.1%) vaccines were marginally more effective than the egg-based quadrivalent vaccines. The cell-cultured quadrivalent vaccines were not significantly more effective than the egg-based quadrivalent vaccines (RVE 2.5%, 95% CI: -2.4 to 7.3%).
CONCLUSIONS
We did not find major effectiveness differences between licensed vaccines used among the elderly during the 2018-19 season. Consistent with prior research, we found that the egg-based adjuvanted and high-dose vaccines were slightly more effective than the egg-based quadrivalent vaccines.
影响因子：
5
作者：
Funk, Michele Jonsson;Westreich, Daniel;Davidian, Marie
通讯作者：
Davidian, Marie