Preserved speech abilities and compensation following prefrontal damage
Preserved speech abilities and compensation following prefrontal damage
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DOI：
10.1073/pnas.93.3.1249
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发表时间：
1996-02-06
影响因子：
11.1
通讯作者：
Petersen, SE
中科院分区：
文献类型：
--
作者：
Buckner, RL;Corbetta, M;Petersen, SE
人类左额叶皮质损伤会导致言语产生障碍（不流利失语症）。这些障碍因受试者而异，并且某些患者在某些言语产生任务上的表现可以相对保留。在这种情况下保留功能的一个可能的解释是，左前额叶皮层以外的区域被用来补偿受伤的大脑区域。我们在此报告了中风患者（LF1）语言功能保留的直接证明，这显然是由于补偿性大脑通路的激活所致。我们使用正电子发射断层扫描（PET）功能性脑成像作为本研究的基础。
Lesions to left frontal cortex in humans produce speech production impairments (nonfluent aphasia). These impairments vary from subject to subject and performance on certain speech production tasks can be relatively preserved in some patients. A possible explanation for preservation of function under these circumstances is that areas outside left prefrontal cortex are used to compensate for the injured brain area. We report here a direct demonstration of preserved language function in a stroke patient (LF1) apparently due to the activation of a compensatory brain pathway. We used functional brain imaging with positron emission tomography (PET) as a basis for this study.