Roles of Rap1 signaling in tumor cell migration and invasion.
Roles of Rap1 signaling in tumor cell migration and invasion.
复制标题
Rap1信号在肿瘤细胞迁移和侵袭中的作用
DOI：
10.20892/j.issn.2095-3941.2016.0086
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发表时间：
2017-02
影响因子：
5.5
通讯作者：
Su L
中科院分区：
文献类型：
--
作者：
Zhang YL;Wang RC;Cheng K;Ring BZ;Su L
Ras 相关蛋白 1 (Rap1) 是 Ras 相关蛋白家族中的一种小 GTP 酶，是基本细胞功能（例如细胞粘附和连接的形成和控制）、细胞迁移和极化的重要调节因子。通过与其他蛋白质的相互作用，Rap1 在不同癌症的细胞侵袭和转移过程中发挥多种作用。 Rap1的基本功能很简单；它在细胞信号转导过程中充当开关，并通过与三磷酸鸟苷 (GTP) 或二磷酸鸟苷 (GDP) 的结合进行调节。然而，其显着多样化的功能是通过其与大量不同的 Rap 鸟嘌呤核苷酸交换因子和 Rap GTPase 激活蛋白的相互作用而呈现的。本文总结了 Rap1 信号传导调节细胞侵袭和转移的机制，重点关注其在整合素和钙粘蛋白调节、Rho GTPase 控制和基质金属蛋白酶表达中的作用。
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate (GTP) or guanosine diphosphate (GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression.