TRANSIENT PIONEER NEURONS ARE ESSENTIAL FOR FORMATION OF AN EMBRYONIC PERIPHERAL-NERVE
TRANSIENT PIONEER NEURONS ARE ESSENTIAL FOR FORMATION OF AN EMBRYONIC PERIPHERAL-NERVE
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DOI：
10.1126/science.2772651
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发表时间：
1989-09-01
期刊：
影响因子：
56.9
通讯作者：
BENTLEY, D
中科院分区：
文献类型：
--
作者：
KLOSE, M;BENTLEY, D
在发育中的神经系统中，许多外周和中枢通路是由早期出现的先驱神经元群体建立的。这些先驱神经元的生长锥可以迁移，而胚胎的距离很短，而干预组织相对简单。这些先驱者有必要吗？在蚱蜢胚胎中，一对先驱神经元出现在肢芽的尖端，并通过肢延伸轴突到中枢神经系统。后来出现的感觉神经元的生长锥沿着先驱轴突迁移。感觉轴突长入后，先锋神经元死亡。如果先驱神经元因热休克而无法分化，那么原本沿着它们迁移的感觉生长锥就会受阻，无法到达中枢神经系统。因此，先锋轴突是这些感觉生长锥成功迁移所必需的。通过在胚胎发生的早期穿越节边界，先驱者规避了分化的节边界细胞和生长锥迁移之间的不相容性。先锋神经元可以解决许多系统中的类似问题。
In developing nervous systems, many peripheral and central pathways are established by early arising populations of pioneer neurons. The growth cones of these pioneer neurons can migrate while embryonic distances are short and while intervening tissue is relatively uncomplicated. Are these pioneers necessary? In grasshopper embryos, a pair of pioneer neurons arise at the tips of limb buds and extend axons through the limb to the central nervous system. Growth cones of later arising sensory neurons migrate along the pioneer axons. After ingrowth of sensory axons, the pioneer neurons die. If the pioneer neurons are prevented from differentiating by heat shock, then the sensory growth cones that would have migrated along them are blocked and fail to reach the central nervous system. Thus, the pioneer axons are necessary for successful migration of these sensory growth cones. By crossing a segment boundary early in embryogenesis, the pioneers circumvent an incompatibility between differentiated segment boundary cells and growth cone migration. Pioneer neurons may resolve similar problems in many systems.