Curing blindness with stem cells: Hope, reality, and challenges
Curing blindness with stem cells: Hope, reality, and challenges
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DOI：
10.1007/978-0-387-74904-4_1
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Adler, Ruben
中科院分区：
文献类型：
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作者：
Adler, Ruben
本文是2006年10月在阿根廷巴里洛切举行的第十二届视网膜变性国际研讨会上的一份报告的摘要，作者在该报告中提出了他个人的观点，即研究正常胚胎发育过程中视网膜细胞的分化可以克服迄今为止阻止通过干细胞移植治疗失明的局限性。该演讲主要以作者实验室中视网膜细胞分化研究的实例进行说明，本文将采用相同的方法;为了更广泛地覆盖该领域，读者可以参考几篇综合评论，例如，（Adler，2000年; Boulton和Albon，2004年; Galli-Resta，2001年; Hatakeyama和Kageyama，2004年; Jean等人，1998; Livesey和Cepko，2001; Lupo等人，2000; Malicki，2004;马夸特和Gruss，2002; Rapaport等人，2004; Vetter和Brown，2001; Zhang等人，2002年）。
This article is a summary of a presentation at the XII International Symposium on Retinal Degeneration in Bariloche, Argentina, in October of 2006, in which the author presented his personal views of the contributions that the study of retinal cell differentiation during normal embryonic development can make towards overcoming the limitations that have so far prevented curing blindness through stem cell transplantation. The talk was illustrated mainly with examples derived from research on retinal cell differentiation in the author's laboratory, and the same approach will be kept in this article; for a broader coverage of the field, the reader is referred to several comprehensive reviews, e.g., (Adler, 2000; Boulton and Albon, 2004; Galli-Resta, 2001; Hatakeyama and Kageyama, 2004; Jean et al., 1998; Livesey and Cepko, 2001; Lupo et al., 2000; Malicki, 2004; Marquardt and Gruss, 2002; Rapaport et al., 2004; Vetter and Brown, 2001; Zhang et al., 2002).