After-effect of entrainment on the period of human circadian system
After-effect of entrainment on the period of human circadian system
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DOI：
10.2170/jjphysiol.49.425
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发表时间：
1999-10-01
期刊：
影响因子：
--
通讯作者：
Honma, K
中科院分区：
文献类型：
--
作者：
Endo, T;Honma, S;Honma, K
本研究的目的是研究人类在时间隔离期间昼夜节律的变化，在这种情况下，昼夜节律是自由运行的。12只年轻雄鼠每人在一间临时隔离室里独自生活了22天。分别于第3天(D3)和第10~13天(D10~D13)监测直肠温度和血浆褪黑素水平。在醒着的时候，房间里的灯光强度不到100IX。D3~D10的体温节律自由流动期(24.75h)与血浆褪黑激素节律(24.63h)和睡眠周期(24.69h)无显著差异。S 1号(D2-D6)的温度节律自由振荡周期为24.58h，S 2号(D6-D10)、S 3号(D12-D16)和S 4号(D-18-D22)的温度节律自由振荡周期逐渐显著延长至24.84h、25.16h和25.18h。在整个隔离期内，直肠温度节律的自由运行时间逐渐延长，这可能是由于先前的夹带对24小时时间提示的后效作用。
The purpose of the present study is to examine changes of the circadian period in humans during temporal isolation, where the circadian rhythm is free-running. Twelve young males each spent 22 d alone in a temporal isolation room. Rectal temperature was continuously recorded and plasma melatonin was measured on day 3 (D3) and from days 10 to 13 (D10-D13). The light intensity in the room was less than 100 Ix during the waking period. The free-run period of temperature rhythm from D3 to D10 (24.75 h) was not significantly different from those of the plasma melatonin rhythm (24.63h) and sleepwake cycle (24.69 h). The free-run period of temperature rhythm was 24.58h in S-1 (D2-D6), which was gradually and significantly lengthened to 24.84 h in S-2 (D6-D10), 25.16 h in S-3 (D12-D16), and 25.18h in S-4 (D-18-D22). The free-run period of rectal temperature rhythm was steadily lengthened throughout the isolation period, which was probably due to the after-effect of previous entrainment to 24-h time cues.