Nonparametric Parameters of 24-Hour Rest-Activity Rhythms and Long-Term Cognitive Decline and Incident Cognitive Impairment in Older Men.
Nonparametric Parameters of 24-Hour Rest-Activity Rhythms and Long-Term Cognitive Decline and Incident Cognitive Impairment in Older Men.
复制标题
老年男性 24 小时休息活动节律的非参数参数以及长期认知衰退和意外认知障碍。
DOI：
10.1093/gerona/glab275
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
OsteoporoticFracturesinMen(MrOS)StudyGroup
中科院分区：
文献类型：
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作者：
Xiao,Qian;Sampson,JoshuaN;LaCroix,AndreaZ;Shadyab,AladdinH;Zeitzer,JamieM;Ancoli-Israel,Sonia;Yaffe,Kristin;Stone,Katie;OsteoporoticFracturesinMen(MrOS)StudyGroup
改变的24小时休息-活动节律可能与老年人的认知障碍有关，但前瞻性研究的证据有限。非参数方法被用来评估活动记录为基础的活动模式在2496老年男性。在12年内，使用改良简易精神状态检查（3 MS）和Trails B测试、自我报告的药物使用和临床诊断对认知障碍事件进行了4次评估。日内变异性的最高四分位数（与最低四分位数相比）和日间稳定性和相对振幅的最低四分位数（与最高四分位数相比）与偶发性认知损害相关（风险比[95%置信区间]分别为：1.82 [1.31-2.53]、1.36 [0.99-1.86]和1.85 [1.33-2.56]）。在7.5年内，每日变异性的较大增加与随后3 MS评分的较大下降相关，但与Trails B性能无关。总之，不太稳定和更多变的休息-活动节律可能是老年男性认知障碍的早期生物标志物。
Altered 24-hour rest–activity rhythms may be associated with cognitive impairment in older adults, but evidence from prospective studies is limited. Nonparametric methods were used to assess actigraphy-based activity patterns in 2 496 older men. Incident cognitive impairment was assessed 4 times over 12 years using the Modified Mini-Mental State Examination (3MS) and Trails B tests, self-reported medication use, and clinical diagnosis. The highest quartile (vs the lowest) of intradaily variability and the lowest quartiles (vs the highest) of interdaily stability and relative amplitude were associated with incident cognitive impairment (hazard ratio [95% confidence interval]: 1.82 [1.31–2.53], 1.36 [0.99–1.86], and 1.85 [1.33–2.56], respectively). A larger increase in intradaily variability over 7.5 years was associated with a greater subsequent decline in 3MS scores but not in Trails B performance. In conclusion, less stable and more variable rest–activity rhythms may represent early biomarkers of cognitive impairment in older men.