CONSERVATION OF BRAIN AMYLOID PROTEINS IN AGED MAMMALS AND HUMANS WITH ALZHEIMERS-DISEASE
CONSERVATION OF BRAIN AMYLOID PROTEINS IN AGED MAMMALS AND HUMANS WITH ALZHEIMERS-DISEASE
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DOI：
10.1126/science.3544219
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发表时间：
1987-02-20
期刊：
影响因子：
56.9
通讯作者：
CORK, LC
中科院分区：
文献类型：
--
作者：
SELKOE, DJ;BELL, DS;CORK, LC
淀粉样纤维细胞外沉积物（神经炎斑块）周围形成的改变的轴突和树突簇是衰老和阿尔茨海默病中人脑的主要特征。一组针对阿尔茨海默病患者淀粉样蛋白丝及其组成蛋白的抗体与其他五种老年哺乳动物（包括猴子、猩猩、北极熊和狗）的神经炎斑块和脑血管淀粉样蛋白沉积物发生交叉反应。代表人类淀粉样蛋白丝部分蛋白质序列的28个氨基酸肽的抗体识别所有老年哺乳动物的皮质和微血管淀粉样蛋白。老年动物中的斑块淀粉样蛋白、斑块神经突和神经元细胞体与人类成对螺旋丝的抗体没有反应。因此，随着年龄的增长，与阿尔茨海默病中进行性皮质变性相关的淀粉样蛋白也沉积在其他哺乳动物的大脑中。老年灵长类动物可以为阿尔茨海默病的主要特征提供生化相关模型：脑血管淀粉样变性和神经炎斑块形成。
The formation of clusters of altered axons and dendrites surrounding extracellular deposits of amyloid filaments (neuritic plaques) is a major feature of the human brain in both aging and Alzheimer''s disease. A panel of antibodies against amyloid filaments and their constituent proteins from humans with Alzheimer''s disease cross-reacted with neuritic plaque and cerebrovascular amyloid deposits in five other species of aged mammals, including monkey, orangutan, polar bear, and dog. Antibodies to a 28-amino acid peptide representing the partial protein sequence of the human amyloid filaments recognized the cortical and microvascular amyloid of all of the aged mammals examined. Plaque amyloid, plaque neurites, and neuronal cell bodies in the aged animals showed no reaction with antibodies to human paired helical filaments. Thus, with age, the amyloid proteins associated with progressive cortical degeneration in Alzheimer''s disease are also deposited in the brains of other mammals. Aged primates can provide biochemically relevant models for principal features of Alzheimer''s disease: cerebrovascular amyloidosis and neuritic plaque formation.