ORIGIN AND DISTRIBUTION OF NORADRENERGIC INNERVATION IN THE HABENULA - A NEUROCHEMICAL STUDY
ORIGIN AND DISTRIBUTION OF NORADRENERGIC INNERVATION IN THE HABENULA - A NEUROCHEMICAL STUDY
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DOI：
10.1016/0006-8993(83)90990-3
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发表时间：
1983-01-01
期刊：
影响因子：
2.9
通讯作者：
GOTTESFELD, Z
中科院分区：
文献类型：
--
作者：
GOTTESFELD, Z
去甲肾上腺素（NE）的分布在大鼠缰（Hb）的离散区域的化学映射。在选择性去传入神经后，定量了外周交感神经和中枢去甲肾上腺素能来源对缰核NE的贡献。NE不均匀地分布在离散的Hb区域中。上级颈神经节切除后，仅内侧血红蛋白（MHb）的去甲肾上腺素（NE）有26%的降低，但差异有显著性（P < 0.05），而外侧血红蛋白（LHb）的NE无明显变化。中枢去甲肾上腺素能神经支配的去传入，如在背侧去甲肾上腺素能束（DNB）的病变，造成了显着减少NE在MHb（53%）和LHb（50%）。损伤背纵束导致NE损失MHb和LHb的31%。这些数据证实了Hb的去甲肾上腺素能神经支配的组织荧光演示。
The distribution of norepinephrine (NE) was chemically mapped in discrete regions of the rat habenula (Hb). The contribution of both peripheral sympathetic and central noradrenergic sources to habenula NE was quantified following selective deafferentations. NE is distributed heterogeneously in discrete Hb regions. After superior cervical ganglionectomy, a small (26%) but significant (P < 0.05) decrease in NE occurred only the medial Hb (MHb), while NE in the lateral Hb (LHb) remained unaltered. Deafferentation of central noradrenergic innervation, such as lesions in the ascending dorsal noradrenergic bundle (DNB), caused a marked decrease in NE in both MHb (53%) and LHb (50%). Lesioning the dorsal longitudinal fasciculus resulted in NE loss in both MHb and LHb by 31%. These data corroborate the histofluorescent demonstration of the noradrenergic innervation of the Hb.