Major anomalies and birth-weight influence NICU interventions and mortality in infants with trisomy 13 or 18
Major anomalies and birth-weight influence NICU interventions and mortality in infants with trisomy 13 or 18
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DOI：
10.1038/jp.2016.245
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发表时间：
2017-04-01
影响因子：
2.9
通讯作者：
Lagatta, J.
中科院分区：
文献类型：
--
作者：
Acharya, K.;Leuthner, S.;Lagatta, J.
目的：描述新生儿重症监护室（NICU）的医疗干预措施和新生儿重症监护室死亡率，按出生体重和主要异常类型为13三体（T13）或18三体（T18）的婴儿。研究设计：回顾性队列分析2005年至2012年Pediatrix医疗集团的T13或118的婴儿。我们根据相关异常类型将婴儿分为三组：新生儿手术，非新生儿手术和轻微异常。结果：从186个新生儿重症监护病房纳入841名婴儿。新生儿重症监护室的死亡率因畸形类型和出生体重的不同而有很大差异，从70%的< 1500 g with neonatal surgical anomalies to 31% of infants >≥ 2500 g的婴儿有轻微畸形。婴儿>= 1500 g无新生儿手术异常包括66%的婴儿入院新生儿重症监护室，他们有最低的新生儿重症监护室的医疗干预和新生儿重症监护室mortality.CONCLUSIONS：风险分层异常类型和出生体重可能有助于提供更准确的家庭咨询的婴儿113和118。
OBJECTIVE: To describe neonatal intensive care unit (NICU) medical interventions and NICU mortality by birth weight and major anomaly types for infants with trisomy 13 (T13) or 18 (T18).STUDY DESIGN: Retrospective cohort analysis of infants with T13 or 118 from 2005 to 2012 in the Pediatrix Medical Group. We classified infants into three groups by associated anomaly type: neonatal surgical, non-neonatal surgical and minor. Outcomes were NICU medical interventions and mortality.RESULTS: 841 infants were included from 186 NICUs. NICU mortality varied widely by anomaly type and birth weight, from 70% of infants < 1500 g with neonatal surgical anomalies to 31% of infants >= 2500 g with minor anomalies. Infants >= 1500 g without a neonatal surgical anomaly comprised 66% of infants admitted to the NICU; they had the lowest rates of NICU medical interventions and NICU mortality.CONCLUSIONS: Risk stratification by anomaly type and birth weight may help provide more accurate family counseling for infants with 113 and 118.