ENZYMATIC GATING OF VOLTAGE-ACTIVATED CALCIUM CHANNELS
ENZYMATIC GATING OF VOLTAGE-ACTIVATED CALCIUM CHANNELS
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DOI：
10.1111/j.1749-6632.1991.tb36478.x
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发表时间：
1991-10-14
期刊：
影响因子：
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通讯作者：
WHITE, RE
中科院分区：
文献类型：
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作者：
ARMSTRONG, DL;ROSSIER, MF;WHITE, RE
上述的钙通道门控模型，虽然几乎肯定过于简单，但表明蛋白激酶和磷酸酶在亚秒级时间尺度上决定钙通道门控动力学中的直接作用。此外，它提供了一个独特的视角来理解广泛不同的代谢和药理条件下的钙通道门控研究。虽然许多这些影响可能是特定的二氢吡啶敏感或L型钙通道，他们给出了一个范围的可能性整合钙通道活性与细胞生物化学的指示。
The model of calcium-channel gating described above, although almost certainly too simple, suggests a direct role for protein kinases and phosphatases in determining the kinetics of calcium channel gating on a subsecond time scale. In addition, it provides a unique perspective for understanding studies of calcium channel gating under widely different metabolic and pharmacological conditions. Although many of these effects may be specific to the dihydropyridine-sensitive or L-type calcium channel, they give an indication of the range of possibilities for integrating calcium-channel activity with cellular biochemistry.