Interaction of Bispyridinium Compounds with Phospholipid Layers in Presence and Absence of Electric Field
Interaction of Bispyridinium Compounds with Phospholipid Layers in Presence and Absence of Electric Field
复制标题
存在和不存在电场时双吡啶鎓化合物与磷脂层的相互作用
DOI：
10.1002/elan.200603723
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发表时间：
2007
期刊：
影响因子：
3
通讯作者：
A. Nelson
中科院分区：
文献类型：
--
作者：
Jon Merrifield;J. Tattersall;M. Bird;A. Nelson
当考虑将具有细胞膜的化合物用于制药应用时，其非特异性生物活性非常重要。本文报道了一组治疗性双吡啶化合物与汞电极（HMDE）上二油酰磷脂酰胆碱（DOPC）磷脂单层的相互作用。记录模型膜系统的阻抗与频率图和电容电位曲线。研究表明化合物对单层的渗透取决于所施加的电场。双吡啶鎓化合物的吸电子取代基和供电子取代基在施加的负电势下促进与化合物的相互作用。
The nonspecific biological activity of compounds with cell membranes is of great importance when considering them for pharmaceutical applications. The interactions of a group of therapeutic bispyridinium compounds with phospholipid monolayers of dioleoyl phosphatidylcholine (DOPC) on a mercury electrode (HMDE) are reported in this paper. Impedance versus frequency plots and capacitance-potential curves were recorded for the model membrane system. The penetration of the compounds into the monolayer is shown to be dependent on the applied electric field. Both electron withdrawing and electron donating substituents of the bispyridinium compounds promote interaction with the compounds at applied negative potential.