Current Status of MicroRNAs that Target the Wnt Signaling Pathway in Regulation of Osteogenesis and Bone Metabolism: A Review.
Current Status of MicroRNAs that Target the Wnt Signaling Pathway in Regulation of Osteogenesis and Bone Metabolism: A Review.
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靶向 Wnt 信号通路的 MicroRNA 在成骨和骨代谢调节中的现状：综述
DOI：
10.12659/msm.929510
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发表时间：
2021-04-08
期刊：
影响因子：
--
通讯作者：
Guo S
中科院分区：
文献类型：
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作者：
Sun Q;Liu S;Feng J;Kang Y;Zhou Y;Guo S
骨间充质干细胞（BMSCs）的定向分化受多种转录因子和细胞内信号通路的调控。过去认为骨髓间充质干细胞的定向分化与骨形态发生蛋白（bone morphogenetic protein， BMP）、MAPK通路等转化生长因子有关。然而，近年来有学者指出，Wnt信号通路作为生物生长发育所必需的复杂的蛋白质相互作用网络，在这一过程中发挥了重要作用，并通过信号转导到细胞中，在调节成骨细胞的发育中起着重要作用。同时，他们也证明了Wnt蛋白治疗确实对骨移植的生存能力和成骨能力有积极的影响。最近的研究表明，microRNAs （miRNAs）在这一过程中起着重要的调节作用。miRNA-218、miRNA-335、miRNA-29、microRNA-30等mirna对Wnt/β-catenin通路中的一些关键分子发挥负或正作用，进而影响骨代谢和骨病。因此，mirna已被认为是一些代谢性骨病的治疗靶点。本文旨在提供针对Wnt信号通路调控成骨和骨代谢的microrna的最新研究现状，并对未来的研究领域进行了讨论，为骨代谢相关疾病的研究提供理论基础。
The directional differentiation of bone mesenchymal stem cells (BMSCs) is regulated by a variety of transcription factors and intracellular signaling pathways. In the past, it was thought that the directional differentiation of BMSCs was related to transforming growth factors, such as bone morphogenetic protein (BMP) and MAPK pathway. However, in recent years, some scholars have pointed out that the Wnt signaling pathway, which is a necessary complex network of protein interactions for biological growth and development, takes a significant role in this process and plays a major part in regulating the development of osteoblasts by exerting signal transduction into cells. Also, they have proved the Wnt protein therapeutic truly have positive effects on the viability and osteogenic capacity of bone graft. Recent studies have shown that microRNAs (miRNAs) play an important regulatory role in this process. MiRNAs such as miRNA-218, miRNA-335, miRNA-29, microRNA-30 and other miRNAs exert negative or positive effects on some crucial molecules in the Wnt/β-catenin pathway, which in turn affect bone metabolism and osteopathy. Thus, miRNAs have been suggested as therapeutic targets for some metabolic bone diseases. This article aims to provide an update on the current status of microRNAs that target the Wnt signaling pathway in the regulation of osteogenesis and bone metabolism and includes a discussion of future areas of research, which can be a theoretical basis for bone metabolism-related diseases.