Validating the Chinese version of the Verbal Learning Test for screening Alzheimer's disease.
Validating the Chinese version of the Verbal Learning Test for screening Alzheimer's disease.
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DOI：
10.1017/s1355617709991184
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发表时间：
2010-03
影响因子：
2.6
通讯作者：
Wang, Pei Ning
中科院分区：
文献类型：
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作者：
Chang, Chiung Chih;Kramer, Joel H.;Lin, Ker Neng;Chang, Wen Neng;Wang, Ya-Ling;Huang, Chi-Wei;Lin, Yu Ting;Chen, Ching;Wang, Pei Ning
情景记忆任务是鉴别阿尔茨海默病（AD）最敏感的工具之一。本研究旨在验证一种较短版本的文字记忆测验，该测验可以有效地评估中国老年人的记忆投诉。对185例认知功能正常的老年人和217例AD患者进行了评估。受试者接受中文版词汇学习测验（CVVLT），该测验包括9个双字名词、4次学习试验、2次30秒和10分钟的延迟回忆和一次单词再认测验。在NC老年人中，年龄和性别对CVVLT中的回忆分数有显着影响，而教育水平与学习，回忆和识别试验中的3种不同模式的错误呈负相关。AD患者在所有回忆测试中的得分均较低。在文化程度较低者中，NC老年人的持续错误率高于AD患者。在10分钟回忆中，AD组和NC组之间的截止值对于年龄>75岁的患者为4/5，对于年龄<75岁的患者为5/6。该研究在区分AD参与者方面具有良好的有效性，这里的数据可以帮助使用CVVLT诊断AD和轻度认知障碍。
Episodic memory tasks are one of the most sensitive tools to discriminate Alzheimer’s disease (AD). This study aimed to validate a shorter version verbal memory test that will efficiently assess Chinese elderly with memory complaints. One hundred and eighty-five elderly with normal cognition (NC) and 217 AD patients were evaluated. Each participant received the Chinese Version Verbal Learning Test (CVVLT) consisting of 9 two-character nouns with 4 learning trials, 2 delayed recalls in 30 seconds and 10 minutes, and a word recognition test. In the NC elderly, age and sex had significant effects on recall scores in CVVLT, while education level showed an inverse correlation with 3 different patterns of errors made during the learning, recall, and recognition trials. AD patients had lower scores across all recall tests. In those with lower educational level, NC elderly had higher perseveration errors than AD patients. The cutoff value between the AD and NC groups in the 10-minute recall was 4/5 for those aged >75 years and 5/6 for those aged <75 years. This study has good validity in discriminating AD participants and the data here can help in diagnosing AD and mild cognitive impairment using the CVVLT.