α-Mangostin: anti-inflammatory activity and metabolism by human cells.
α-Mangostin: anti-inflammatory activity and metabolism by human cells.
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DOI：
10.1021/jf4004434
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发表时间：
2013-04-24
影响因子：
6.1
通讯作者：
Failla ML
中科院分区：
文献类型：
--
作者：
Gutierrez-Orozco F;Chitchumroonchokchai C;Lesinski GB;Suksamrarn S;Failla ML
关于α-山竹素（α-MG）（山竹果实中最丰富的氧杂蒽酮）在人体细胞中的抗炎活性和代谢的信息有限。根据现有文献，我们假设 α-MG 将通过控制和激活巨噬细胞样 THP-1、肝 HepG2、肠细胞样 Caco-2 和结肠 HT-29 人类细胞系以及原代人单核细胞衍生巨噬细胞 (MDM) 抑制促炎介质的分泌，并且这种活性会受到呫吨酮代谢程度的影响。 α-MG 减弱了各种细胞系的 TNF-α 和 IL-8 分泌，但增加了静态和 LPS 处理的 MDM 的 TNF-α 输出。添加 α-MG 后 24 小时，培养基中存在的 α-MG 和其他呫吨酮的游离代谢物和 II 期代谢物的相对量因细胞类型和炎症损伤而异。氧杂蒽酮及其代谢物跨 Caco-2 细胞单层的转运增加表明炎症发作期间吸收增强。氧杂蒽酮及其代谢物在不同组织中的抗炎活性值得考虑。
Information about the anti-inflammatory activity and metabolism of α-mangostin (α-MG), the most abundant xanthone in mangosteen fruit, in human cells is limited. On the basis of available literature, we hypothesized that α-MG will inhibit the secretion of pro-inflammatory mediators by control and activated macrophage-like THP-1, hepatic HepG2, enterocyte-like Caco-2, and colon HT-29 human cell lines, as well as primary human monocyte-derived macrophages (MDM), and that such activity would be influenced by the extent of metabolism of the xanthone. α-MG attenuated TNF-α and IL-8 secretion by the various cell lines but increased TNF-α output by both quiescent and LPS-treated MDM. The relative amounts of free and phase II metabolites of α-MG and other xanthones present in media 24 h after addition of α-MG was shown to vary by cell type and inflammatory insult. Increased transport of xanthones and their metabolites across Caco-2 cell monolayers suggests enhanced absorption during an inflammatory episode. The anti-inflammatory activities of xanthones and their metabolites in different tissues merit consideration.
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