Molecular Mechanisms of Anti-cancer Action of Garlic Compounds in Neuroblastoma
Molecular Mechanisms of Anti-cancer Action of Garlic Compounds in Neuroblastoma
复制标题
DOI：
10.2174/187152011795677553
复制
发表时间：
2011-05-01
影响因子：
2.8
通讯作者：
Ray, Swapan K.
中科院分区：
文献类型：
--
作者：
Karmakar, Surajit;Choudhury, Subhasree Roy;Ray, Swapan K.
大蒜（Allium sativum）的药用价值自古以来就为人们所熟知和广泛使用。在过去的几年里，大蒜化合物因其癌症化学预防特性而受到越来越多的关注。大蒜衍生的有机硫化合物（OSCs）的抗癌活性在许多癌症中被广泛报道，但在儿童肿瘤神经母细胞瘤中却很少报道，这需要探索新的治疗方法。最近有一些报道表明，大蒜来源的OSCs在恶性神经母细胞瘤中引起细胞周期阻滞，产生活性氧（ROS），激活应激激酶，并刺激线粒体凋亡途径。OSCs在神经母细胞瘤中的综合抗癌机制尚不清楚，有待进一步研究。本综述旨在强调大蒜来源的OSCs在神经母细胞瘤和其他几种癌症中的抗癌作用的已知分子机制。大蒜源性OSCs治疗人类恶性神经母细胞瘤的临床有效性有待进一步研究。
The medicinal properties of garlic (Allium sativum) have been well known and widely used since historical times. Garlic compounds have received increasing attention during the last few years due to their cancer chemopreventive properties. The anti-cancer activity of garlic-derived organosulfur compounds (OSCs) are extensively reported in many cancers but only a few in the pediatric tumor neuroblastoma, which warrants exploration of new therapy for its management. There are some recent reports suggesting that garlic-derived OSCs cause cell cycle arrest, generate reactive oxygen species (ROS), activate stress kinases, and also stimulate the mitochondrial pathway for apoptosis in malignant neuroblastoma. The comprehensive mechanisms of anti-cancer action of OSCs still remain unclear and require more studies in neuroblastoma. This review is designed to highlight the known molecular mechanisms of anti-cancer actions of garlic-derived OSCs in neuroblastoma and as well as in several other cancers. Further studies should be conducted to establish the clinical expediency of garlic-derived OSCs for treatment of malignant neuroblastoma in humans.