Inhibitory control in rats performing a stop-signal reaction-time task:: Effects of lesions of the medial striatum and d-amphetamine
Inhibitory control in rats performing a stop-signal reaction-time task:: Effects of lesions of the medial striatum and d-amphetamine
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DOI：
10.1037/0735-7044.117.6.1302
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发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Eagle, DM;Robbins, TW
停止信号任务衡量的是抑制已经启动的响应的能力，即停止的能力。影像研究表明，额纹状体回路参与了这种形式的反应控制。作者报告了正常大鼠和纹状体内侧受损大鼠执行停止信号任务的抑制功能。内侧纹状体的兴奋毒性损伤导致任务绩效显著下降，包括GO任务中遗漏增加和抑制功能平坦，这可能是由于反应时平均值和变异性增加的结果。纹状体内侧损害也显著减慢了停止信号反应时间。随后使用d-苯丙胺的治疗消除(0.3毫克/公斤)或加剧(1.0毫克/公斤)这一缺陷。
The stop-signal task measures the ability to inhibit a response that has already been initiated, that is, the ability to stop. Imaging studies have implicated frontostriatal circuitry in the mediation of this form of response control. The authors report inhibition functions of normal rats and those with medial striatal damage performing the stop-signal task. Excitotoxic lesions of the medial striatum produced significant deficits on task performance, including increased omissions on the go task and flattened inhibition function, possibly as a result of increased reaction-time mean and variability. Medial striatal lesions also significantly slowed stop-signal reaction time. Subsequent treatment with d-amphetamine removed (0.3 mg/kg) or exacerbated (1.0 mg/kg) this deficit.