Expression and functional significance of the J11d marker on mouse thymocytes.
Expression and functional significance of the J11d marker on mouse thymocytes.
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DOI：
10.4049/jimmunol.138.7.2013
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发表时间：
1987-04
影响因子：
4.4
通讯作者：
I. Crispe;M. Bevan
中科院分区：
文献类型：
--
作者：
I. Crispe;M. Bevan
胸腺细胞的亚群已被表征的表型和功能相关的单克隆抗体J11 d所定义的标记物的表达。皮质型L3 T4+、Lyt-2+胸腺细胞均为J11 d+。与外周Lyt-2+ T细胞共享表型L3 T4-、Lyt-2+的胸腺细胞含有J11 d+和J11 d-亚群。这些J11 d-细胞在两种功能测定中表现得像外周Lyt-2+ T细胞：它们响应于针对T细胞抗原受体的固定化抗体而形成克隆生长爆发，并且它们充当同种异体反应性细胞毒性T细胞的前体。J11 d+细胞在这两种试验中均呈惰性。相反，L3 T4+，Lyt-2-胸腺细胞不包含J11 d+亚群。
Subpopulations of thymocytes have been characterized phenotypically and functionally in relation to their expression of the marker defined by the monoclonal antibody J11d. Cortical-type L3T4+, Lyt-2+ thymocytes are all J11d+. Thymocytes that share the phenotype L3T4-, Lyt-2+ with peripheral Lyt-2+ T cells contain a J11d+ and a J11d- subset. These J11d- cells behave like peripheral Lyt-2+ T cells in two functional assays: they form clonal growth bursts in response to immobilized antibody against the T cell antigen receptor, and they act as precursors of alloreactive cytotoxic T cells. The J11d+ cells are inert in both of these assays. In contrast, L3T4+, Lyt-2- thymocytes do not contain a J11d+ subset.